Ignite Creation Date:
2024-05-05 @ 10:17 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001972
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2000-01-18
Brief Title:
PET Scan of Brain Metabolism in Relation to Age and Disease
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Positron Emission Tomography Imaging of Human Brain Phospholipid Metabolism in Relation to Age and Disease
Status:
COMPLETED
Status Verified Date:
2002-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The main source of energy for the brain comes from a combination of oxygen and glucose sugar For brain cells to function normally they must receive a constant supply of these nutrients As areas of the brain become more active blood flow into and out of these areas increase
In addition to oxygen and glucose the brain uses chemical compounds known as phospholipids These phospholipids make up the covering of nerve cells that assist in the transfer of information from cell to cell Without phospholipids brain cell activity may become abnormal and cause problems in the nervous system
Certain diseases like Alzheimers disease and brain tumors can affect blood flow to the brain and change the way the brain metabolizes phospholipids In addition to diseases changes in the brain occur with normal healthy aging
This study is designed to use PET scan to measure changes in blood flow and changes in phospholipid metabolism Using this technique researchers can improve their understanding of how certain diseases change the shape and function of the brain
In addition to oxygen and glucose the brain uses chemical compounds known as phospholipids These phospholipids make up the covering of nerve cells that assist in the transfer of information from cell to cell Without phospholipids brain cell activity may become abnormal and cause problems in the nervous system
Certain diseases like Alzheimers disease and brain tumors can affect blood flow to the brain and change the way the brain metabolizes phospholipids In addition to diseases changes in the brain occur with normal healthy aging
This study is designed to use PET scan to measure changes in blood flow and changes in phospholipid metabolism Using this technique researchers can improve their understanding of how certain diseases change the shape and function of the brain
Detailed Description:
The Brain Physiology and Metabolism Section BPMS of the National Institute on Aging NIA and the Clinical Neuroscience Program CNP of the National Institute of Neurological Disorders and Stroke NINDS propose to study regional brain phospholipid metabolism in young and old normal volunteers and in patients with Alzheimer disease The method to be employed developed from animal studies involves the intravenous injection of a radiolabeled polyunsaturated fatty acid 11Carachidonic acid and measuring regional brain radioactivity using positron emission tomography PET A mathematical model is used to calculate regional brain incorporation coefficients k of 11Carachidonate into brain These reflect brain signal transduction and membrane turnover involving phospholipids and the signal transduction and membrane turnover involving phospholipids and the activation of the enzyme phospholipase A2 PET also will be used in the same subjects to measure regional cerebral blood flow rCBF a marker of brain energy metabolism with radioactive water 150H20 The literature reports that rCBF and energy metabolism decline with age and are markedly reduced in Alzheimer disease We hypothesize that a we will be able to quantify and image incorporation of 11Carachidonate into the human brain for the first time b in normal volunteers k for arachidonate will be correlated on a regional basis with rCBF c rCBF will be reduced in the older compared with the younger normal volunteers and markedly reduced in Alzheimer disease patients compared with the older volunteers controls d the normal coupling regression relation between k and rCBF will be disturbed in Alzheimer disease
This protocol originally proposed to measure brain incorporation of two labeled fatty acids 11Carachidonate and 11Cpalmitate as well as rCBF in young and old normal volunteers and in patients with Alzheimer disease Niemann-Pick Type C disease and brain tumors Eleven patients with Alzheimer disease have been scanned using 11Carachidonate and 150H20 compared with 10 volunteers The current amendment proposes to use only 11Carachidonate and 150H20 in 16 additional normal volunteers and to compare the results between old and young groups and patients with Alzheimer disease A request to study only 16 additional normal volunteers was approved by the NINDS IRB at the Continuing Review in 1999 and has not changed since then
This protocol originally proposed to measure brain incorporation of two labeled fatty acids 11Carachidonate and 11Cpalmitate as well as rCBF in young and old normal volunteers and in patients with Alzheimer disease Niemann-Pick Type C disease and brain tumors Eleven patients with Alzheimer disease have been scanned using 11Carachidonate and 150H20 compared with 10 volunteers The current amendment proposes to use only 11Carachidonate and 150H20 in 16 additional normal volunteers and to compare the results between old and young groups and patients with Alzheimer disease A request to study only 16 additional normal volunteers was approved by the NINDS IRB at the Continuing Review in 1999 and has not changed since then
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 94-N-0205 | None | None | None |