Ignite Creation Date:
2024-05-06 @ 2:20 AM
Last Modification Date:
2024-10-26 @ 11:17 AM
Study NCT ID:
NCT02024919
Status:
COMPLETED
Last Update Posted:
2015-05-06
First Post:
2013-12-29
Brief Title:
Effect of Diltiazem on Coronary Artery Ectasia
Sponsor:
Ankara University
Organization:
Ankara University
Study Overview
Official Title:
Short Term Effect of Diltiazem on Myocardial Perfusion in Patients With Isolated Coronary Artery Ectasia- a Prospective Clinical Study
Status:
COMPLETED
Status Verified Date:
2015-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Coronary artery ectasia CAE has been defined as localized or diffuse dilatation of epicardial coronary arteries more than 15 fold of adjacent normal segments Isolated CAE constitutes minor portion of the total CAE cases with an incidence of 01 to 079 in which coronary artery stenosis or severe valvular heart diseases are not present CAE represents not only an anatomical variant but also a clinical constellation of coronary artery disease CAD like association with myocardial ischemia and acute coronary syndromes Patients with CAE without significant coronary narrowing may still present with angina pectoris positive stress tests or acute coronary syndromes Impaired epicardial and microvascular perfusion were demonstrated in ectatic coronary arteries
Myocardial blush grading MBG technique has been utilized in various conditions such as acute myocardial infarction coronary artery ectasia syndrome X and idiopathic dilated cardiomyopathy to evaluate myocardial perfusion
There is still no consensus for management of CAE Previously improvement of coronary flow has been demonstrated by mibefradil in patients with slow coronary flow A new trial is needed to explore the effect of calcium channel blockers CCB in isolated CAE Diltiazem improves myocardial perfusion by blocking calcium channels in coronary arteries This agent has been widely used in coronary catheter labs to prevent and treat no-reflow
The current study with prospective design was therefore set up to assess whether epicardial flow and tissue level perfusion would be improved by diltiazem in myocardial regions subtended by the ectatic coronary arteries among patients with isolated CAE
Myocardial blush grading MBG technique has been utilized in various conditions such as acute myocardial infarction coronary artery ectasia syndrome X and idiopathic dilated cardiomyopathy to evaluate myocardial perfusion
There is still no consensus for management of CAE Previously improvement of coronary flow has been demonstrated by mibefradil in patients with slow coronary flow A new trial is needed to explore the effect of calcium channel blockers CCB in isolated CAE Diltiazem improves myocardial perfusion by blocking calcium channels in coronary arteries This agent has been widely used in coronary catheter labs to prevent and treat no-reflow
The current study with prospective design was therefore set up to assess whether epicardial flow and tissue level perfusion would be improved by diltiazem in myocardial regions subtended by the ectatic coronary arteries among patients with isolated CAE
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None