Ignite Creation Date:
2024-05-05 @ 11:50 AM
Last Modification Date:
2024-10-26 @ 9:14 AM
Study NCT ID:
NCT00149175
Status:
UNKNOWN
Last Update Posted:
2010-03-15
First Post:
2005-09-06
Brief Title:
Clinical and Genetic Study of Neurodegenerative Disorders With Cognitive Impairment
Sponsor:
Institut National de la Santé Et de la Recherche Médicale France
Organization:
Institut National de la Santé Et de la Recherche Médicale France
Study Overview
Official Title:
Clinical and Genetic Study of Neurodegenerative Disorders With Cognitive Impairment
Status:
UNKNOWN
Status Verified Date:
2010-03
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Patients with different types of dementia will be recruited and evaluated in national hospital departments for their usual neurological follow-ups A blood sample will be proposed in the field of this research project and the biological material will be stored at the DNA and Cell Bank of Institut de Fédératif Recherche IFR of Neurosciences Pitié-Salpêtrière Hospital Paris The clinical research network is already set up for Alzheimers disease and frontotemporal dementias which permits an evaluation according to a clinical standardized protocol
Among these disorders a monogenic sub-group has been identified In Alzheimers disease it is associated with the APP PSEN1 and PSEN2 genes which account only for 75 of the familial forms with early onset In frontotemporal dementias the tau gene mutations account only for 10 of the cases with an autosomal dominant inheritance The identification of familial forms with a genetic inquiry in the relatives is essential for a greater knowledge of the molecular bases of forms not caused by the known genes using linkage approaches and candidate gene analysis The familial forms are also useful for identifying the modifier genes
In the multifactorial forms the aim is to assemble a wide cohort of patients and controls matched for localizing and identifying susceptibility genetic factors The strategies will use a candidate gene approach and in the near future studies of single nucleotide polymorphisms SNPs spread out in the whole genome Meanwhile similar approaches particularly with candidate genes could be used for identifying predictive factors of tolerance and response to the treatment
Finally correlations will be performed with seric markers according to each kind of dementia
Specialized clinical teams in diagnosis and follow-up in dementias are assembled for this project and in the study of neurological disorders of genetic origin
Among these disorders a monogenic sub-group has been identified In Alzheimers disease it is associated with the APP PSEN1 and PSEN2 genes which account only for 75 of the familial forms with early onset In frontotemporal dementias the tau gene mutations account only for 10 of the cases with an autosomal dominant inheritance The identification of familial forms with a genetic inquiry in the relatives is essential for a greater knowledge of the molecular bases of forms not caused by the known genes using linkage approaches and candidate gene analysis The familial forms are also useful for identifying the modifier genes
In the multifactorial forms the aim is to assemble a wide cohort of patients and controls matched for localizing and identifying susceptibility genetic factors The strategies will use a candidate gene approach and in the near future studies of single nucleotide polymorphisms SNPs spread out in the whole genome Meanwhile similar approaches particularly with candidate genes could be used for identifying predictive factors of tolerance and response to the treatment
Finally correlations will be performed with seric markers according to each kind of dementia
Specialized clinical teams in diagnosis and follow-up in dementias are assembled for this project and in the study of neurological disorders of genetic origin
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 02-346A10 | None | None | None |