Ignite Creation Date:
2024-05-06 @ 2:17 AM
Last Modification Date:
2024-10-26 @ 11:15 AM
Study NCT ID:
NCT02001766
Status:
UNKNOWN
Last Update Posted:
2015-06-16
First Post:
2013-11-19
Brief Title:
ATP Release and Sympathetic Nerve Activity in Patients With Type II Diabetes
Sponsor:
Anders Rasmussen Rinnov
Organization:
Rigshospitalet Denmark
Study Overview
Official Title:
ATP Release and Sympathetic Nerve Activity in Patients With Type II Diabetes
Status:
UNKNOWN
Status Verified Date:
2015-06
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Type II diabetes T2D is characterized by endothelial dysfunction resulting in a poor tissue perfusion and function as well as an increased risk of cardiovascular events ATP which is released from the red blood cells contributes to the regulation of the blood flow and studies have shown that red blood cells taken from T2D patients have an impaired ability to release ATP However it is not known whether the changes in the ATP system is an underlying cause of the poor tissue perfusion observed in T2D The purpose of project 1 is to test the hypothesis that the deterioration in blood flow in T2D is caused by a reduced release ATP from red blood cells and to test if pharmacological manipulation of cAMP will normalize ATP release plasma ATP levels and thereby blood flow
Furthermore epidemiological studies show a clear link between regular exercise and a reduced risk of serious cardiovascular disease The extent to which a physically active lifestyle may improve endothelial function in T2D is unknown Regular physical activity improves vascularization and induces an anti-inflammatory environment Both the angiogenic and anti-inflammatory effects of physical activity is in part mediated by substances released from the active muscle These muscle-derived substances are classified as myokines and have paracrine autocrine and endocrine effects and may thereby affect distant tissues The purpose of the project 2 is to investigate whether high intensity interval training may reverse endothelial dysfunction in T2D through increased release of ATP and myokines In individuals with T2D we will determined blood flow in the muscle tissue using advanced ultrasound In addition using intravascular and intramuscular microdialysis we will determine ATP levels in blood and in the muscle interstitium
Furthermore epidemiological studies show a clear link between regular exercise and a reduced risk of serious cardiovascular disease The extent to which a physically active lifestyle may improve endothelial function in T2D is unknown Regular physical activity improves vascularization and induces an anti-inflammatory environment Both the angiogenic and anti-inflammatory effects of physical activity is in part mediated by substances released from the active muscle These muscle-derived substances are classified as myokines and have paracrine autocrine and endocrine effects and may thereby affect distant tissues The purpose of the project 2 is to investigate whether high intensity interval training may reverse endothelial dysfunction in T2D through increased release of ATP and myokines In individuals with T2D we will determined blood flow in the muscle tissue using advanced ultrasound In addition using intravascular and intramuscular microdialysis we will determine ATP levels in blood and in the muscle interstitium
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None