Ignite Creation Date:
2024-05-05 @ 11:50 AM
Last Modification Date:
2024-10-26 @ 9:14 AM
Study NCT ID:
NCT00146055
Status:
COMPLETED
Last Update Posted:
2012-08-09
First Post:
2005-09-01
Brief Title:
Low-Intensity Preparation and Allogeneic Transplant in Patients With Cancers of the Blood
Sponsor:
University of Michigan Rogel Cancer Center
Organization:
University of Michigan Rogel Cancer Center
Study Overview
Official Title:
Low-Intensity Preparative Regimen and Allogeneic Peripheral Blood Stem Cell Transplantation From Unrelated Donor in Patients With Hematologic Malignancy
Status:
COMPLETED
Status Verified Date:
2012-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to determine whether a less-intensive preparative therapy followed by an allogeneic peripheral stem cell transplantation will provide an effective treatment for your disease and whether it will be associated with fewer side effects
Detailed Description:
Combinations of high-dose chemotherapy and radiation therapy preparative regimen followed with allogeneic bone marrow or stem cell transplantation from an unrelated donor is a current treatment approach Chemotherapeutic drugs and radiation are given in higher doses to increase their effectiveness High-dose chemotherapy and radiation therapy generally affect cells that are dividing They are used to treat cancer because cancer cells divide more often than most other cells High-dose treatment severely damages the patients bone marrow so that the patient no longer is able to produce needed blood cells Peripheral stem cell transplantation allows stem cells that were damaged by treatment to be replaced with healthy stem cells that can produce the blood cells the patient needs Patients experience a number of complications after transplantation Some are temporary and relatively minor yet others can be life threatening Many doctors consider high-dose chemotherapy by itself or with radiation and bone marrow or stem cell transplantation as the best available treatment option for diseases under specific circumstances However this study will explore whether a less-intensive preparative therapy before the peripheral stem cell transplantation will prove to be safer have less side effects and be an effective treatment for certain diseases
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None