Ignite Creation Date:
2024-05-06 @ 2:14 AM
Last Modification Date:
2024-10-26 @ 11:15 AM
Study NCT ID:
NCT01992666
Status:
COMPLETED
Last Update Posted:
2018-07-26
First Post:
2013-11-08
Brief Title:
GENetic Immunologic Abnomalies in Systemic Lupus Erythematosus
Sponsor:
Hospices Civils de Lyon
Organization:
Hospices Civils de Lyon
Study Overview
Official Title:
GENetic Immunologic Abnomalies in Systemic Lupus Erythematosus
Status:
COMPLETED
Status Verified Date:
2018-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
GENIAL
Brief Summary:
Systemic Lupus Erythematosus SLE is a chronic autoimmune disease for which the aetiology includes genet-ic and environmental factors It is rare in children as compared to adults The severity may be related to greater involvement of genetic factors in children The impact of genetics in the development of SLE is important and the risk of recurrence in siblings evaluated by lambda S ratio is 30 in SLE while it is 15 for type-1 diabetes and 8 rheumatoid arthritis thereby indicating high impact of genetics in SLE
Recently the group of Professor Yanick Crow in Manchester and other teams has identified new forms of lupus Mendelian genetics The TREX1 and genes involved in the SAMHD1 frostbite lupus
Nearly 2 of all adult subjects with SLE have a heterozygous mutation in the TREX1 gene which therefore represents the first genetic cause of SLE The team of Professor Crow also identified the ACP5 gene that is responsible for SLE associated with Spondylo-epiphyseal enchondro-epiphyseal dysplasia syndromic lupus Other groups have identified mutations in two genes encoding a DNAse DNAse1 and DNAse1L3 responsible for familial monogenic forms of SLE These new genes SLE were identified through research of germ-line mutations in cases of lupus syndromic or family In collaboration with Professor Crow we are currently undergoing characterization of a novel gene of SLE in a family and we have identified a second locus identified in another family The identification of these genes provides a better understanding of the mechanisms regulating immune tolerance in humans The frequency of these genetic forms is not known There is very little data on the immunological phenotype of these patients
This is a clinical study to investigate the genetic and immunological abnormalities associated with pediatric SLE The aim are to
study the genetics of pediatric SLE or syndromic or family and to search for mutations in the known genetic lupus or new genes in collaboration with Professor Yanick Crow
study the lymphocyte subpopulations and serum cytokines in pediatric patients with SLE or syndromic or family in the large Rhône- Alpes- Auvergne area
Recently the group of Professor Yanick Crow in Manchester and other teams has identified new forms of lupus Mendelian genetics The TREX1 and genes involved in the SAMHD1 frostbite lupus
Nearly 2 of all adult subjects with SLE have a heterozygous mutation in the TREX1 gene which therefore represents the first genetic cause of SLE The team of Professor Crow also identified the ACP5 gene that is responsible for SLE associated with Spondylo-epiphyseal enchondro-epiphyseal dysplasia syndromic lupus Other groups have identified mutations in two genes encoding a DNAse DNAse1 and DNAse1L3 responsible for familial monogenic forms of SLE These new genes SLE were identified through research of germ-line mutations in cases of lupus syndromic or family In collaboration with Professor Crow we are currently undergoing characterization of a novel gene of SLE in a family and we have identified a second locus identified in another family The identification of these genes provides a better understanding of the mechanisms regulating immune tolerance in humans The frequency of these genetic forms is not known There is very little data on the immunological phenotype of these patients
This is a clinical study to investigate the genetic and immunological abnormalities associated with pediatric SLE The aim are to
study the genetics of pediatric SLE or syndromic or family and to search for mutations in the known genetic lupus or new genes in collaboration with Professor Yanick Crow
study the lymphocyte subpopulations and serum cytokines in pediatric patients with SLE or syndromic or family in the large Rhône- Alpes- Auvergne area
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 2012-A01449-34 | OTHER | ID-RCB | None |