Ignite Creation Date:
2024-05-06 @ 2:13 AM
Last Modification Date:
2024-10-26 @ 11:15 AM
Study NCT ID:
NCT01999608
Status:
COMPLETED
Last Update Posted:
2016-06-02
First Post:
2013-11-18
Brief Title:
Vitamin D Deficiency and Ovarian Reserve Among Infertile Patients
Sponsor:
Universitair Ziekenhuis Brussel
Organization:
Universitair Ziekenhuis Brussel
Study Overview
Official Title:
Vitamin D Deficiency and Ovarian Reserve Among Infertile Patients A Cross-sectional Analysis
Status:
COMPLETED
Status Verified Date:
2016-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The role of vitamin D deficiency in female reproduction remains controversial Early retrospective studies were inconsistent regarding the effect of serum 25-OH vitamin D levels on pregnancy rates in women undergoing in vitro fertilization IVF whereas two retrospective studies postulated that vitamin D deficiency may negatively affect pregnancy rates with an effect mediated through the endometrium
Taking into account that knock-out experiments have shown that vitamin D receptor null mice not only experience uterine hypoplasia but also impaired folliculogenesis it might be hypothesized that vitamin D deficiency may have a detrimental effect on female ovarian reserve This may be further supported by previous reports demonstrating that serum 25-OH Vitamin D levels correlates with antimullerian hormone AMH levels in women of advanced reproductive age
The aim of this study is to examine through a large set of prospectively recruited infertile women whether serum 25-OH-Vitamin D levels is related with the 2 most widely accepted biomarkers of ovarian reserve serum AMH levels and antral follicle count AFC
Taking into account that knock-out experiments have shown that vitamin D receptor null mice not only experience uterine hypoplasia but also impaired folliculogenesis it might be hypothesized that vitamin D deficiency may have a detrimental effect on female ovarian reserve This may be further supported by previous reports demonstrating that serum 25-OH Vitamin D levels correlates with antimullerian hormone AMH levels in women of advanced reproductive age
The aim of this study is to examine through a large set of prospectively recruited infertile women whether serum 25-OH-Vitamin D levels is related with the 2 most widely accepted biomarkers of ovarian reserve serum AMH levels and antral follicle count AFC
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None