Ignite Creation Date:
2024-05-05 @ 11:50 AM
Last Modification Date:
2024-10-26 @ 9:14 AM
Study NCT ID:
NCT00148980
Status:
WITHDRAWN
Last Update Posted:
2011-04-28
First Post:
2005-09-07
Brief Title:
Creation of Bone Marrow Microenvironment for Treatment of Myelodysplastic Syndrome MDS in Conjunction With Allogeneic Stem Cell Transplantation
Sponsor:
Hadassah Medical Organization
Organization:
Hadassah Medical Organization
Study Overview
Official Title:
Creation of Bone Marrow Microenvironment for Treatment of MDS in Conjunction With Allogeneic Stem Cell Transplantation
Status:
WITHDRAWN
Status Verified Date:
2006-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
the PI is no longer work at Hadassah
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Normal bone marrow function depends on the coexistence of normal hematopoietic stem cells and a microenvironment mostly located in the medullary part of the bones Stem cells cannot function properly in the absence of an adequate microenvironment Whereas in malignant and non-malignant hematologic diseases caused by a deficiency or abnormal stem cells stem cell transplantation is the treatment of choice that results in a cure in diseases such as MDS myelofibrosis and other conditions associated with an abnormal microenvironment pancytopenia may occur despite the presence of apparently normal hematopoietic cells with no recognizable cytogenetic abnormality
We the investigators at Hadassah Medical Organization proved in experimental studies that the entire osteohematopoietic complex consisting of trabecular bone hematopoietic microenvironment of stromal origin and hematopoietic tissue has been successfully transferred directly into ablated bone marrow cavity in a one-step transplantation procedure
The goal of this study is to enhance hematopoiesis in patients with myelofibrosis syndrome by intraosseous inoculation of demineralized bone matrix DBM together with allogeneic bone marrow cells BMC
We the investigators at Hadassah Medical Organization proved in experimental studies that the entire osteohematopoietic complex consisting of trabecular bone hematopoietic microenvironment of stromal origin and hematopoietic tissue has been successfully transferred directly into ablated bone marrow cavity in a one-step transplantation procedure
The goal of this study is to enhance hematopoiesis in patients with myelofibrosis syndrome by intraosseous inoculation of demineralized bone matrix DBM together with allogeneic bone marrow cells BMC
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None