Ignite Creation Date:
2024-05-06 @ 2:12 AM
Last Modification Date:
2024-10-26 @ 11:15 AM
Study NCT ID:
NCT01992848
Status:
COMPLETED
Last Update Posted:
2017-04-25
First Post:
2013-10-23
Brief Title:
MAP-Calcification MicroRNAs as Potential Biomarkers for Coronary Artery Calcification
Sponsor:
University of Surrey
Organization:
University of Surrey
Study Overview
Official Title:
A Case-control Study of MicroRNAs a Potential Biomarkers for Coronary Artery Calcification CAC - An Additional Substudy to Determine the Relationship Between CAC and Bone Mineral Density and Markers of Bone Metabolism
Status:
COMPLETED
Status Verified Date:
2017-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Coronary artery disease CAD remains the leading cause of mortality in the UK with an estimated 80000 fatalities in 2010 Coronary artery calcification CAC is associated with atherosclerotic plaque burden and cardiovascular mortality Mechanisms underlying isolated CAC have not been as yet been fully explained MicroRNAs miRNAs known to act as regulators of gene expression have also emerged as powerful biomarkers in the diagnosis and prognosis of cardiovascular disorders and may be used in the detection of CAC We aim to investigate the potential for a microRNA-signature in patients with CAC by performing a prospective case-controlled study to identify pathways associated with CAC in humans Previous research has demonstrated an inverse relationship between CAC and bone mineral density BMD suggesting that these processes may be linked In a further substudy we plan to define the relationship between CAC and BMD as well as a number of markers of bone metabolism
Detailed Description:
Patients will be prospectively enrolled whilst attending for elective coronary CT computed tomography angiography including a coronary calcium score at the Royal Surrey County Hospital Data regarding demographic and clinical characteristics of patients will be collected Peripheral venous blood sampling will take place on this occasion Coronary artery calcification scores will be estimated by a Radiologist using default software Patients eligible for the bone metabolism substudy will be required to attend the University of Surrey for peripheral Quantitative Computed Tomography pQCT of bone mineral composition of the radius In the intervening period we will ask them to complete a 4-day food diary and wear a UV dosimeter the latter to assess typical UV exposure for one week
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None