Ignite Creation Date:
2024-05-06 @ 2:08 AM
Last Modification Date:
2024-10-26 @ 11:14 AM
Study NCT ID:
NCT01977885
Status:
COMPLETED
Last Update Posted:
2015-09-25
First Post:
2013-10-16
Brief Title:
Exercise-Induced Epigenetic Modifications in Obese Aging Women
Sponsor:
University of Georgia
Organization:
University of Georgia
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2015-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
DIVAS2
Brief Summary:
Our greatest public health challenge is obesity and the co-morbidities of metabolic syndrome MetS Age is an established risk factor for MetS and specific to women data indicates that the prevalence of MetS increases substantially with the menopausal transition with postmenopausal women having a 60 increased risk of MetS Menopause also contributes to reductions in strength physical function and often psychological well-being eg fatigue Obese individuals also have a impaired immune function and chronic inflammatory responses associated with changes in the white blood cell population in blood and fat tissues and b increased secretion of and signaling by proteins in their fat cells Weight loss which requires an energy deficit through increased physical activity andor caloric restriction EXCR reduces risk for MetS in older sedentary obese women by reducing insulin resistance and chronic systemic inflammation Science and clinical practice will be advanced by examining the molecular mechanisms by which EXCR affects risk for MetS in older women The primary aim is to determine if CD4 T cells will report the differential epigenetic reprogramming of relevant gene expression associated with metabolic indices resulting from EXCR induced weight loss in older women known to be at risk for MetS This pilot data will be used to generate an NIH proposal of the same topic A secondary aim is to assess the impact of weight loss on physical function and psychological well-being which will provide pilot data for an additional grant proposal regarding weight management in postmenopausal women
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None