Ignite Creation Date:
2024-05-05 @ 11:50 AM
Last Modification Date:
2024-10-26 @ 9:14 AM
Study NCT ID:
NCT00145366
Status:
COMPLETED
Last Update Posted:
2010-12-28
First Post:
2005-09-02
Brief Title:
rhTSH Thyroid Size and Radioiodine Therapy in Benign Goiter
Sponsor:
Odense University Hospital
Organization:
Odense University Hospital
Study Overview
Official Title:
Pretreatment With Recombinant Human Thyrotropin rhTSH for the Effect on Thyroid Size and Function and for the Effect of Radioiodine Treatment in Patients With Nodular Goiter Prospective Randomized Double-blinded Trials
Status:
COMPLETED
Status Verified Date:
2009-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The trials in this protocol deals with the effect of pretreatment with rhTSH on radioiodine treatment of thyroid size and function in patients with nontoxic and toxic nodular goiter It is an introduction of a novel principle based on prospective randomized double blind investigations Attached to this we investigate the acute effects of rhTSH on thyroid size measured by ultrasonography both in healthy individuals and in patients with nontoxic nodular goiter Thus the investigations are divided into 4 categories listed below
1 Prospective randomized double blind study of pretreatment with 03 mg recombinant human TSH for the effect of radioiodine in nontoxic multinodular goiter
2 Prospective randomized double blind study of the pretreatment with 03 mg recombinant human TSH for the effect of radioiodine on thyroid size and function in patients with a very large 100 ml nontoxic or toxic goiter
3 Does administration of 09 mg recombinant human TSH affect thyroid function and volume in healthy individuals A randomized double-blind cross-over trial
4 Does administration of 03 mg recombinant human TSH affect thyroid function and volume in healthy individuals and in patients with multinodular non-toxic goiter A randomized double-blind cross-over trial
As a final note we investigate in a pilot-study
5 The influence of rhTSH on thyroid radioiodine uptake in patients with hyperthyroidism treated with continuous block-replacement therapy
1 Prospective randomized double blind study of pretreatment with 03 mg recombinant human TSH for the effect of radioiodine in nontoxic multinodular goiter
2 Prospective randomized double blind study of the pretreatment with 03 mg recombinant human TSH for the effect of radioiodine on thyroid size and function in patients with a very large 100 ml nontoxic or toxic goiter
3 Does administration of 09 mg recombinant human TSH affect thyroid function and volume in healthy individuals A randomized double-blind cross-over trial
4 Does administration of 03 mg recombinant human TSH affect thyroid function and volume in healthy individuals and in patients with multinodular non-toxic goiter A randomized double-blind cross-over trial
As a final note we investigate in a pilot-study
5 The influence of rhTSH on thyroid radioiodine uptake in patients with hyperthyroidism treated with continuous block-replacement therapy
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None