Ignite Creation Date:
2024-05-05 @ 11:49 AM
Last Modification Date:
2024-10-26 @ 9:14 AM
Study NCT ID:
NCT00142636
Status:
UNKNOWN
Last Update Posted:
2005-11-22
First Post:
2005-09-01
Brief Title:
CRICKET Study Coronary Calcium Scores in Patients With Chronic Kidney Disease
Sponsor:
United States Naval Medical Center San Diego
Organization:
United States Naval Medical Center San Diego
Study Overview
Official Title:
Coronary Artery Calcification in Chronic Kidney Disease Using Multidetector Row Spiral Computed Tomography
Status:
UNKNOWN
Status Verified Date:
2005-08
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Patients with Chronic Kidney Disease CKD have been shown to have high coronary calcium scores CAC but the temporal association between Glomerular Filtration Rate CVD risk factors and CAC has not been described This is a single-center longitudinal observational study Subjects included adults aged 18 years to 65 years old without preexisting coronary artery disease CAD The CKD subjects GFR 60 mlmin and the control subjects GFR 60mlmin were recruited Laboratory measurements and MDCT scan were performed at baseline and after 12 months Baseline CAC and average intact parathyroid hormone iPTH level were significantly greater in the CKD group Baseline CAC scores of the CKD group were twice the value of the control group however CAC scores over one year were unchanged from baseline
Detailed Description:
Patients with Chronic Kidney Disease CKD have been shown to have high coronary calcium scores CAC but the temporal association between Glomerular Filtration Rate CVD risk factors and CAC has not been described This is a single-center longitudinal observational study Subjects included adults aged 18 years to 65 years old without preexisting coronary artery disease CAD The CKD subjects GFR 60 mlmin were recruited from the Nephrology Clinic and the control subjects GFR 60mlmin were recruited from the Internal Medicine Clinic Laboratory measurements and MDCT scan were performed at baseline and after 12 months Baseline CAC and average intact parathyroid hormone iPTH level were significantly greater in the CKD group Baseline CAC scores of the CKD group were twice the value of the control group however CAC scores over one year were unchanged from baseline These observations suggest that CAC begins in earlier stages of CKD Moreover novel CVD risk factors including iPTH may accelerate CAD progression in CKD
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| CRADA CIP S-03-133 | None | None | None |