Ignite Creation Date:
2024-05-06 @ 2:05 AM
Last Modification Date:
2024-10-26 @ 11:13 AM
Study NCT ID:
NCT01968096
Status:
UNKNOWN
Last Update Posted:
2013-10-23
First Post:
2013-10-16
Brief Title:
The Reversal of Neuromuscular Adaptation in Human With Spinal Cord Injury II
Sponsor:
Chang Gung University
Organization:
Chang Gung University
Study Overview
Official Title:
None
Status:
UNKNOWN
Status Verified Date:
2013-10
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Following injury to the spinal cord the spinal circuit undergoes a series of adaptations In parallel with the spinal circuit adaptation the muscular properties also adapt In human and animal studies histochemical and physiological evidences showed that the paralyzed muscle transferred from slow fatigue-resistant to fast fatigable after injury
Reversal of neuromuscular property for persons with SCI needs to be resolved Studies using high load electrical stimulations showed a reverse change of muscular properties such as hypertrophy and reversal of fiber type transformations but failed to show a reversal of spinal circuitry function Previous studies found that fast continuous passive motion CPM altered the H reflex excitability in human Animal studies found that passive cycling and passive stretching delayed atrophy and influenced the transition of type I and IIa MHC Theses findings lead to a hypothesis that mechanical stimulation might be able to reverse both spinal circuitry and muscular properties after SCI but it has not been confirmed in human study
The purpose of this project is to investigate the effect of mechanical stimulation by fast CPM on the reversing adaptation of human paralyzed muscle after SCI
Reversal of neuromuscular property for persons with SCI needs to be resolved Studies using high load electrical stimulations showed a reverse change of muscular properties such as hypertrophy and reversal of fiber type transformations but failed to show a reversal of spinal circuitry function Previous studies found that fast continuous passive motion CPM altered the H reflex excitability in human Animal studies found that passive cycling and passive stretching delayed atrophy and influenced the transition of type I and IIa MHC Theses findings lead to a hypothesis that mechanical stimulation might be able to reverse both spinal circuitry and muscular properties after SCI but it has not been confirmed in human study
The purpose of this project is to investigate the effect of mechanical stimulation by fast CPM on the reversing adaptation of human paralyzed muscle after SCI
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| NSC102-2314-B-182-021-MY2 | None | None | None |