Ignite Creation Date:
2024-05-05 @ 11:49 AM
Last Modification Date:
2024-10-26 @ 9:14 AM
Study NCT ID:
NCT00147524
Status:
COMPLETED
Last Update Posted:
2007-04-30
First Post:
2005-09-02
Brief Title:
Non-Comparative Study To Evaluate Changes In FMD After Quinapril Therapy In Hypertensive Women
Sponsor:
Pfizer
Organization:
Pfizer
Study Overview
Official Title:
Multicenter Open-Label Non-Comparative Study To Evaluate Changes In Flow Mediated Dilatation During And After A 6 Months Treatment Period With Step By Step Increased Doses With Quinapril Therapy In Post-Menopausal Women With Mild Or Moderate Hypertension
Status:
COMPLETED
Status Verified Date:
2007-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
ACE inhibitors are thought to modify the endothelium in a number of ways Quinapril is an effective and well-tolerated ACE-I for the treatment of patients with hypertension and congestive heart failure Quinapril produces favourable haemodynamic changes and improves ventricular and endothelial function in patients with various cardiovascular disorders These effects are mediated through the binding of quinaprilat to both tissue and plasma-ACE
Quinapril 10 to 40 mg once daily improved endothelial function as measured by improved FMD or reduced vasoconstrictiveincreased vasodilative response to Ach in patients with CAD and hypertension over 2 to 6 months of therapy improved endothelial function was also observed in patients with CHF receiving a single infusion of quinaprilat In general quinapril showed neutral or beneficial effects on lipid profiles glycaemia and renal haemodynamics 3 There are no data available considering effects of quinapril on endothelial dysfunction in post- menopausal woman with mild to moderate hypertension and with pathological endothelial function
Quinapril 10 to 40 mg once daily improved endothelial function as measured by improved FMD or reduced vasoconstrictiveincreased vasodilative response to Ach in patients with CAD and hypertension over 2 to 6 months of therapy improved endothelial function was also observed in patients with CHF receiving a single infusion of quinaprilat In general quinapril showed neutral or beneficial effects on lipid profiles glycaemia and renal haemodynamics 3 There are no data available considering effects of quinapril on endothelial dysfunction in post- menopausal woman with mild to moderate hypertension and with pathological endothelial function
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None