Ignite Creation Date:
2024-05-05 @ 11:49 AM
Last Modification Date:
2024-10-26 @ 9:14 AM
Study NCT ID:
NCT00148278
Status:
COMPLETED
Last Update Posted:
2010-07-22
First Post:
2005-09-01
Brief Title:
Norepinephrine Plus Dobutamine Versus Epinephrine Alone for the Management of Septic Shock
Sponsor:
University of Versailles
Organization:
University of Versailles
Study Overview
Official Title:
Prospective Multicenter Randomized Double-Blind Study Comparing Safety and Efficacy of Norepinephrine Plus Dobutamine Versus Epinephrine Alone in Septic Shock
Status:
COMPLETED
Status Verified Date:
2010-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
CATS
Brief Summary:
Catecholamines infusion is a major component of septic shock management International guidelines recommend that norepinephrine should be preferred to epinephrine though phase III trials are lacking The present study aimed at comparing the efficacy and safety of norepinephrine plus dobutamine to that of epinephrine in adults with septic shock
Detailed Description:
The french Conference on Consensus on catecholamines use in septic shock has underlined the importance of carrying out a clinical trial to clarify the use of epinephrine norepinephrine and dobutamine in the management of multiple organ failure associated with severe sepsis The main objective of the study was therefore to compare the effects of the combination of dobutamine and norepinephrine to those of epinephrine alone in patients with septic shock In this purpose patients were randomly assigned to receive either epinephrine or norepinephrine plus dobutamine and drugs were titrated to maintain blood pressure over 70 mmHg Main outcome was 28-day mortality
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| CIC0203001 | None | None | None |
| AOM97123 | None | None | None |