Ignite Creation Date:
2024-05-06 @ 1:58 AM
Last Modification Date:
2024-10-26 @ 11:12 AM
Study NCT ID:
NCT01944709
Status:
TERMINATED
Last Update Posted:
2013-09-18
First Post:
2013-09-13
Brief Title:
Phase III Study of Vaccination With Antigen Loaded Dendritic Cells DCs in Patients With Inoperable Stage III and Stage IV Melanoma
Sponsor:
Prof Dr Silke Gillessen
Organization:
Cantonal Hospital of St Gallen
Study Overview
Official Title:
Phase III Study of Vaccination With Antigen Loaded Dendritic Cells DCs in Patients With Inoperable Stage III and Stage IV Melanoma
Status:
TERMINATED
Status Verified Date:
2013-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Progressive Disease
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The prognosis of patients with metastatic melanoma is poor and current available treatments are limited Identification of a number of melanoma-specific tumor antigens that are shared by tumors from different patients provides attractive targets for immune-based therapies httpwwwbioinfoorgcnhptaa Different approaches like DNA-RNA-vaccines peptide vaccines and dendritic cell DC vaccines are under investigation to induce peptide-specific immune responses In various animal models and in clinical trials it was shown that the most potent induction of anti tumor-specific killer cells was achieved with DC vaccination DCs are professional antigen presenting cells APC that are critical in the initiation of cellular responses in naïve T lymphocytes in vivo They are armed with all the molecules needed for the induction of immune responses and have the capacity to migrate into secondary lymphatic organs In vitro generated dendritic cells are loaded with tumor derived peptides and injected subcutaneously The concept is to induce or to propagate already existing tumor specific killer T cells
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None