Ignite Creation Date:
2024-05-05 @ 11:49 AM
Last Modification Date:
2024-10-26 @ 9:14 AM
Study NCT ID:
NCT00147082
Status:
COMPLETED
Last Update Posted:
2019-12-05
First Post:
2005-09-06
Brief Title:
Leukocyte Function in Chronic Obstructive Pulmonary Disease COPD
Sponsor:
Imperial College London
Organization:
Imperial College London
Study Overview
Official Title:
Leukocyte Migration and Differentiation in COPD Patients Compared to Healthy Smokers and Healthy Non-smoking Subjects
Status:
COMPLETED
Status Verified Date:
2019-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this study is to investigate the mechanisms whereby leukocytes are recruited to the lung in chronic obstructive pulmonary disease COPD and cause tissue destruction The hypothesis is that in COPD more leukocytes enter the lung and it is these cells that are responsible for the degradation of lung tissue We the researchers at Imperial College London will isolate leukocytes from the blood of patients with COPD healthy smokers and normal subjects and measure the movement of the leukocytes to chemoattractants We will examine further which cell surface receptors are responsible for this trafficking of cells Furthermore the differentiation of these cells in vitro will be compared with cells from healthy smokers and normal subjects Specifically the expression of enzymes that are responsible for tissue destruction and the cell surface receptors on these cells will be investigated The objective is to identify the mechanisms whereby leukocytes from COPD patients behave differently to cells from healthy smokers and normal subjects with a view to identify novel targets for drug therapy
Detailed Description:
Chemotaxis experiments will be performed in order to ascertain the migratory characteristics of leukocytes towards specific chemoattractants Comparisons of cells from different subjects will be compared In addition the effects of various pharmaceutical interventions on this mechanism will also be addressed and compared within subject groups In some experiments cells will be differentiated in vitro and their cellular expression and regulation of inflammatory mediators and chemoattractants examined Again comparisons will be made between subject groups and the efficacy of various pharmacological agents on these cells
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None