Ignite Creation Date:
2024-05-05 @ 11:49 AM
Last Modification Date:
2024-10-26 @ 9:14 AM
Study NCT ID:
NCT00140842
Status:
COMPLETED
Last Update Posted:
2021-11-02
First Post:
2005-08-30
Brief Title:
Neuroendocrine Modulation of Metabolic Effects in Overweight Adolescents
Sponsor:
Massachusetts General Hospital
Organization:
Massachusetts General Hospital
Study Overview
Official Title:
Neuroendocrine Modulation of Metabolic Effects in Overweight Adolescents
Status:
COMPLETED
Status Verified Date:
2021-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will examine hormonal differences in ghrelin and growth hormone in obese and normal weight adolescents and their relationship to body composition and insulin resistance The study will also investigate the effect of the macronutrient composition of a meal on postprandial ghrelin levels and whether ghrelin responses will predict the degree of hunger and caloric intake at a subsequent meal
Detailed Description:
Obesity is an epidemic that is striking people at younger ages than ever before Obesity is associated with changes in the secretory patterns of several hormones including ghrelin growth hormone GH and insulin which have not been examined in the adolescent age group Ghrelin a primarily gastric hormone increases appetite and is a GH secretagogue This study will compare the alteration in secretion of ghrelin and GH in overweight and normal weight adolescent girls through frequent blood sampling and GH stimulation testing with growth hormone releasing hormone and arginine The relationship between these hormones and insulin resistance measured by 1H-nuclear magnetic resonance spectroscopy and body composition measured by dual energy x-ray absorptiometry and magnetic resonance imaging will be investigated This study will also determine the postprandial ghrelin response to test meals that vary by the type of predominant macronutrient which may predict the degree of hunger and amount of intake at a subsequent meal Understanding obesity-related changes in ghrelin and GH and their relationship to body composition insulin resistance and appetite will help in the development of strategies to reduce complications of obesity
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None