Ignite Creation Date:
2024-05-06 @ 1:55 AM
Last Modification Date:
2024-10-26 @ 11:11 AM
Study NCT ID:
NCT01928355
Status:
UNKNOWN
Last Update Posted:
2013-08-30
First Post:
2013-08-20
Brief Title:
Cognitive Dysfunction in People Who Are Obese But Metabolically Healthy
Sponsor:
Ziv Hospital
Organization:
Ziv Hospital
Study Overview
Official Title:
None
Status:
UNKNOWN
Status Verified Date:
2013-08
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
There is some evidence to suggest that obesity is a risk factor for the development of cognitive dysfunction although this is not a universal finding This discordance might be ascribed to the existence of a healthy obese phenotype- that is obesity in the absence of metabolic risk factors We examined whether the association of obesity with cognitive dysfunction is dependent on the individuals metabolic health
60 obese patients undergoping liver fibroscan and blood tests will be enrolled Obesity was defined as body mass index 30 kgm2 Based on blood pressure HDL-cholesterol triglycerides glycated haemoglobin and C-reactive protein participants were classified as metabolically healthy 0 or 1 metabolic abnormality or unhealthy 2 metabolic abnormalities Cognitive dysfunction will be assessed by moca and minimental score Results Cognitive dysfunction prevalence is expected in 30 but 50 of this group was categorized as metabolically healthy Relative to non-obese healthy participants after adjustment for baseline covariates the metabolically unhealthy obese participants had elevated risk of cognitive dysfunction although the metabolically healthy obese did not The association between obesity and risk of cognitive dysfunction appears to be partly dependent on metabolic health although further work is required to confirm these findings
In obesity there is an increase in oxidative stress due to metabolic syndrome Thus obese patients suffer from higher incidences of cardiovascular complications such as atherosclerosis as compare to non- obese population Haptoglobin Hp is a plasma protein which binds free hemoglobin and prevents it from heme- iron mediated oxidation There are three different types of Hp which differ in their antioxidant ability Several clinical studies have shown that Hp 2-2 genotype is associated with higher incidence of cardiovascular diseases
60 obese patients undergoping liver fibroscan and blood tests will be enrolled Obesity was defined as body mass index 30 kgm2 Based on blood pressure HDL-cholesterol triglycerides glycated haemoglobin and C-reactive protein participants were classified as metabolically healthy 0 or 1 metabolic abnormality or unhealthy 2 metabolic abnormalities Cognitive dysfunction will be assessed by moca and minimental score Results Cognitive dysfunction prevalence is expected in 30 but 50 of this group was categorized as metabolically healthy Relative to non-obese healthy participants after adjustment for baseline covariates the metabolically unhealthy obese participants had elevated risk of cognitive dysfunction although the metabolically healthy obese did not The association between obesity and risk of cognitive dysfunction appears to be partly dependent on metabolic health although further work is required to confirm these findings
In obesity there is an increase in oxidative stress due to metabolic syndrome Thus obese patients suffer from higher incidences of cardiovascular complications such as atherosclerosis as compare to non- obese population Haptoglobin Hp is a plasma protein which binds free hemoglobin and prevents it from heme- iron mediated oxidation There are three different types of Hp which differ in their antioxidant ability Several clinical studies have shown that Hp 2-2 genotype is associated with higher incidence of cardiovascular diseases
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None