Ignite Creation Date:
2024-05-05 @ 11:48 AM
Last Modification Date:
2024-10-26 @ 9:14 AM
Study NCT ID:
NCT00148161
Status:
UNKNOWN
Last Update Posted:
2007-04-27
First Post:
2005-09-06
Brief Title:
Activity of the Auditory Cortex During Speech Perception and Speech Production in Stuttering
Sponsor:
University Hospital Muenster
Organization:
University Hospital Muenster
Study Overview
Official Title:
Evoked and Induced Auditory Cortical Activity During Speech Perception and Speech Production in Stuttering
Status:
UNKNOWN
Status Verified Date:
2006-09
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of the study is to examine the cortical activity during speech perception and speech production in idiopathic stutterers compared to fluent speakers Therefore the noninvasive method of magnetoencephalography MEG is used A better understanding for the complexity of speech perception and its pathology should be developed
Fundamental properties of stuttering are repetitions prolongations and blocks In most cases stuttering emerges between 2 and 5 years of age The auditory feedback should become less important during development as soon as information about mispronounced words does not occur anymore During speech development this control function should be adopted by other systems In stutterers the dominance of the acoustic control should remain
Brain imaging studies with positron emission tomography PET or magnetic resonance imaging MRI show defects in the network of motor system in the lateralization of speech areas and functions of the auditory cortex Magnetoencephalographic studies describe a similar variety as cause of stuttering There may be defects in the auditory feedback a modification of the lateralization of speech areas or an alteration of co-action of motor planning and auditory system
The benefit of magnetoencephalography is a very good temporal resolution in the range of milliseconds combined with good spatial resolution Therefore it is well suited to examine the dynamics of cortical processing during stuttering In this study evoked components of the auditory systems related to complex sounds vocals consonant-vocal combinations and single words are analyzed Differences of these components in the auditory cortices of stutterers and fluent speakers are hypothesized as well in temporal structure as in localization and lateralization
Fundamental properties of stuttering are repetitions prolongations and blocks In most cases stuttering emerges between 2 and 5 years of age The auditory feedback should become less important during development as soon as information about mispronounced words does not occur anymore During speech development this control function should be adopted by other systems In stutterers the dominance of the acoustic control should remain
Brain imaging studies with positron emission tomography PET or magnetic resonance imaging MRI show defects in the network of motor system in the lateralization of speech areas and functions of the auditory cortex Magnetoencephalographic studies describe a similar variety as cause of stuttering There may be defects in the auditory feedback a modification of the lateralization of speech areas or an alteration of co-action of motor planning and auditory system
The benefit of magnetoencephalography is a very good temporal resolution in the range of milliseconds combined with good spatial resolution Therefore it is well suited to examine the dynamics of cortical processing during stuttering In this study evoked components of the auditory systems related to complex sounds vocals consonant-vocal combinations and single words are analyzed Differences of these components in the auditory cortices of stutterers and fluent speakers are hypothesized as well in temporal structure as in localization and lateralization
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None