Ignite Creation Date:
2024-05-06 @ 1:51 AM
Last Modification Date:
2024-10-26 @ 11:10 AM
Study NCT ID:
NCT01915654
Status:
TERMINATED
Last Update Posted:
2016-07-22
First Post:
2013-08-02
Brief Title:
Impact of RBC Transfusion Less Than 14 Days on Morbidity and Mortality in Cardiac Surgical Patients
Sponsor:
Centre Hospitalier Universitaire de Besancon
Organization:
Centre Hospitalier Universitaire de Besancon
Study Overview
Official Title:
Impact de la Transfusion de Culots Globulaires de Moins de 14 Jours Sur la Morbi-mortalité Chez Des Patients en Chirurgie Cardiaque
Status:
TERMINATED
Status Verified Date:
2013-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Retrospective study from December 2007 to May 2010
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
CGRCard
Brief Summary:
The purpose of the transfusion of packed red blood cell is to overcome acute or chronic anemia cause tissue hypoxia It increases hemoglobin concentration and consequently increase oxygen delivery to peripheral tissues The perioperative period of major surgery is a field particularly favorable to the development of tissue hypoxia which is associated with increased mortality and postoperative morbidity Optimization of oxygen transport to tissues at the preoperative period is accompanied by a significant reduction of these major complications
Clinical complications infectious or otherwise related to transfusion of caps Red Blood cells Caps RBCare well known Many studies seem to evidence the potentially deleterious effect of transfusion especially in patients with poor condition related to storage time Indeed during storage impaired blood-related storage is created It is metabolic biochemical and molecular levels Many studies carried out in particular in cardiac surgery where patients are suitable for transfusion RBC have focused on the effect of transfusions on consumption and the transport of oxygen to demonstrate the impact of conservation lesions on their role in vivo In particular a single-center retrospective American study showed reduction of postoperative complications in patients who received RBC under 14 days
However one of the confounding factors present is that all transfused RBCs are not leukoreduced unlike the French transfusion policy In addition the greater part of the clinical studies are controversial That is why we aim to assess through a retrospective study of data the impact of transfusion of red red blood cells within 14 days of post-operative morbidity and mortality compared to the usual transfusion practice in cardiac surgery patients
Clinical complications infectious or otherwise related to transfusion of caps Red Blood cells Caps RBCare well known Many studies seem to evidence the potentially deleterious effect of transfusion especially in patients with poor condition related to storage time Indeed during storage impaired blood-related storage is created It is metabolic biochemical and molecular levels Many studies carried out in particular in cardiac surgery where patients are suitable for transfusion RBC have focused on the effect of transfusions on consumption and the transport of oxygen to demonstrate the impact of conservation lesions on their role in vivo In particular a single-center retrospective American study showed reduction of postoperative complications in patients who received RBC under 14 days
However one of the confounding factors present is that all transfused RBCs are not leukoreduced unlike the French transfusion policy In addition the greater part of the clinical studies are controversial That is why we aim to assess through a retrospective study of data the impact of transfusion of red red blood cells within 14 days of post-operative morbidity and mortality compared to the usual transfusion practice in cardiac surgery patients
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None