Ignite Creation Date:
2024-05-06 @ 1:47 AM
Last Modification Date:
2024-10-26 @ 11:09 AM
Study NCT ID:
NCT01890369
Status:
UNKNOWN
Last Update Posted:
2014-01-17
First Post:
2013-06-26
Brief Title:
Modulation of Muscle Protein Metabolism by Essential Amino Acids
Sponsor:
University of Nottingham
Organization:
University of Nottingham
Study Overview
Official Title:
Modulation of Muscle Protein Metabolism by Essential Amino Acids
Status:
UNKNOWN
Status Verified Date:
2014-01
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
Aj1B
Brief Summary:
The investigators plan to explore the ability of amino acids the building blocks of proteins in our bodies and in the food we eat to stimulate muscles to grow and stay strong The investigators will investigate how rapidly after one meal the human body is ready to make use of a second meal and look at the molecular mechanisms underlying this The investigators will look at these phenomena in older men as this group is known to be subject to a gradual loss of muscle mass and strength
Detailed Description:
Muscles can stay very constant in size for much of adult life yet dramatic wasting is seen in advanced age and ill health A better understanding of how muscles regulate their size will help design treatments to slow wasting in disease and to promote active aging We plan to study a group of older men 70yrs the age at which muscle bulk starts to decrease to observe how the muscles respond to feeding We will provide a drink that contains the digested products of proteins from which muscles are built Taking blood samples and some tiny biopsies of muscle done under local anaesthesia will allow us to measure muscle turnover and we will be able to measure for how long after a meal muscles actively take in nutrients before becoming full We will also measure how long the muscle remains full before it returns to a state where it can again be stimulated to take in nutrients We will also explore if leucine one of the component parts of protein especially in meat and dairy products and a food widely used supplement can promote the early re-stimulation of muscle by eating
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None