Ignite Creation Date:
2024-05-05 @ 11:48 AM
Last Modification Date:
2024-10-26 @ 9:13 AM
Study NCT ID:
NCT00131040
Status:
COMPLETED
Last Update Posted:
2015-05-28
First Post:
2005-08-15
Brief Title:
Investigation of Leukocyte Trafficking Into Skin Blisters During Cardiopulmonary Bypass
Sponsor:
Imperial College London
Organization:
Imperial College London
Study Overview
Official Title:
Investigation of Leukocyte Trafficking Into Skin Blisters During Cardiopulmonary Bypass
Status:
COMPLETED
Status Verified Date:
2005-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study was to see if the heart-lung machine involved in cardiac surgery increases the movement of activated white blood cells from the bloodstream into the patients tissues and also to see if aprotinin usage during surgery reduces this effect
Detailed Description:
It has long been known that exposure of blood to the heart-lung bypass machine can trigger a whole-body inflammatory response in cardiac surgery patients that is linked to activation of circulating white blood cells The investigators propose to use a technique to track the movement of white blood cells into the skin of patients during bypass surgery The skin blisters will be elicited by application of the blistering agent cantharidin to the forearm of volunteer patients This will allow the investigators to study the activation state of white blood cells that enter tissues during bypass surgery and to determine whether aprotinin has any beneficial effect with regards to inflammatory status of these cells
The investigators propose that white blood cell trafficking into the blisters will increase following the use of the heart-lung machine and that the effect of aprotinin will be to ablate this
The investigators propose that white blood cell trafficking into the blisters will increase following the use of the heart-lung machine and that the effect of aprotinin will be to ablate this
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None