Ignite Creation Date:
2024-05-06 @ 1:47 AM
Last Modification Date:
2024-10-26 @ 11:09 AM
Study NCT ID:
NCT01897961
Status:
COMPLETED
Last Update Posted:
2024-02-12
First Post:
2012-07-20
Brief Title:
Phospholipase A2 Receptor PLA2R1 Autoantibodies in Membranous Nephropathy in Kidney Transplantation
Sponsor:
Centre Hospitalier Universitaire de Nice
Organization:
Centre Hospitalier Universitaire de Nice
Study Overview
Official Title:
Phospholipase A2 Receptor PLA2R1 Autoantibodies in Membranous Nephropathy in Kidney Transplantation
Status:
COMPLETED
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PRAM-KT
Brief Summary:
The Membranous nephropathy GEMidiopatic is the most frequent cause of syndrome néphrotique at the adult and represent approximately 2 of the causes of terminal chronic renal insufficiency A etiology balance assessment must be systematically realized to eliminate a secondary cause Antibodies managed against the receiver of phospholipases A2 secreted by type M PLA2R1 was recently detected in a population of GEM idiopatic but not secondary GEM PLA2R1 is expressed by the podocytes of the glomerules of healthy subjects and this receiver co-is located with the deposits of extramembraneous IgG of the expanding subjects of idiopathique GEM The good IgG the extramembraneous depositsof GEM idiopathic recognize PLA2R1 At some patients the activity anti-PLA2R1 seems to decrease or to disappear during the stake in forgiveness of the disease
Some cases of second offense of GEM idiopathique after renal transplantation presenting antibodies anti-PLA2R1 have also described The appearance of antibody anti-PLA2R1 seems parallel to the increase of a proteinurie in touch with a second offense of GEM and antibodies sometimes disappeared after a therapeutic strengthening by Rituximab allowing to obtain a forgiveness
A GEM can also appear of novo on the renal transplant it is to say without notion of GEM on the native loins The physiopathology of this affection remains unknown
Working hypothesis and objectives We shall look in which proportion the presence of antibody anti-PLA2R1 is associated with the second offense of GEM idiopathic in renal transplantation We anticipate that the GEM of novo of the renal transplant answers a different physiopathology and will not be associated with the presence of antibody anti-PLA2R1 We hope to demonstrate that at the expanding patients of antibody anti-PLA2R1 the title of these antibodies is correlated in the activity of the disease and in the renal survival and that the longitudinal follow-up of the title of these antibodies has an interest forecast and therapeutics
Some cases of second offense of GEM idiopathique after renal transplantation presenting antibodies anti-PLA2R1 have also described The appearance of antibody anti-PLA2R1 seems parallel to the increase of a proteinurie in touch with a second offense of GEM and antibodies sometimes disappeared after a therapeutic strengthening by Rituximab allowing to obtain a forgiveness
A GEM can also appear of novo on the renal transplant it is to say without notion of GEM on the native loins The physiopathology of this affection remains unknown
Working hypothesis and objectives We shall look in which proportion the presence of antibody anti-PLA2R1 is associated with the second offense of GEM idiopathic in renal transplantation We anticipate that the GEM of novo of the renal transplant answers a different physiopathology and will not be associated with the presence of antibody anti-PLA2R1 We hope to demonstrate that at the expanding patients of antibody anti-PLA2R1 the title of these antibodies is correlated in the activity of the disease and in the renal survival and that the longitudinal follow-up of the title of these antibodies has an interest forecast and therapeutics
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None