Ignite Creation Date:
2024-05-05 @ 11:48 AM
Last Modification Date:
2024-10-26 @ 9:13 AM
Study NCT ID:
NCT00136188
Status:
COMPLETED
Last Update Posted:
2012-06-19
First Post:
2005-08-25
Brief Title:
Nitric Oxide NO Activity and Diabetic Nephropathy
Sponsor:
University of Erlangen-Nürnberg Medical School
Organization:
University of Erlangen-Nürnberg Medical School
Study Overview
Official Title:
Role of NO Activity for the Development of Diabetic Nephropathy
Status:
COMPLETED
Status Verified Date:
2012-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Experimental data suggest that oxidative stress and endothelial dysfunction are key players in the pathogenesis of diabetic nephropathy In the last few years the investigators were able to establish a method to assess endothelial function of the renal vasculature in humans and started to systematically study a variety of cardiovascular disorders known to be associated with endothelial dysfunction in other vascular beds including hypertension hypercholesterolemia and type-2 diabetes In patients with type-2 diabetes the investigators could demonstrate that despite unaltered basal and stimulated NO-activity the renal response to the antioxidant vitamin C was more pronounced compared to control subjects These data suggest that oxidative stress is increased in the renal vasculature of diabetic patients Furthermore NO-activity in diabetic patients appears to be upregulated to compensate for the increase in oxidative stress This hypothesis is supported by the demonstration of increased endothelial nitric oxide synthase eNOS expression in kidney biopsies of diabetic patients
The major focus of the investigators current research activities is to assess the role of endothelial dysfunction in the very early stages of diabetic nephropathy To this end patients with increased fasting glucose or metabolic syndrome will be studied in comparison with an age-matched control group Endothelial function and the role of oxidative stress will be assessed in the renal vasculature in all groups In parallel the investigators will study endothelial function in the forearm by venous occlusion plethysmography and in the retinal vasculature by scanning laser doppler flowmetry to dissect regional differences in the regulation of endothelial function Further aspects include the role of microalbuminuria glomerular hyperfiltration and endogenous inhibitors of NO synthase such as NGNG-Dimethyl-L-Arginine ADMA In a therapeutic approach the investigators will determine the effects of various antioxidant treatment strategies on endothelial function and their potential role in the prevention of diabetic nephropathy
The major focus of the investigators current research activities is to assess the role of endothelial dysfunction in the very early stages of diabetic nephropathy To this end patients with increased fasting glucose or metabolic syndrome will be studied in comparison with an age-matched control group Endothelial function and the role of oxidative stress will be assessed in the renal vasculature in all groups In parallel the investigators will study endothelial function in the forearm by venous occlusion plethysmography and in the retinal vasculature by scanning laser doppler flowmetry to dissect regional differences in the regulation of endothelial function Further aspects include the role of microalbuminuria glomerular hyperfiltration and endogenous inhibitors of NO synthase such as NGNG-Dimethyl-L-Arginine ADMA In a therapeutic approach the investigators will determine the effects of various antioxidant treatment strategies on endothelial function and their potential role in the prevention of diabetic nephropathy
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None