Ignite Creation Date:
2024-05-06 @ 1:45 AM
Last Modification Date:
2024-10-26 @ 11:09 AM
Study NCT ID:
NCT01897636
Status:
UNKNOWN
Last Update Posted:
2013-07-12
First Post:
2013-07-09
Brief Title:
Efficacy and Safety of Endoscopic Ultrasound Guided Fine-needle Injection of Dendritic Cells Vaccination Into Unresectable Pancreatic Cancer
Sponsor:
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Organization:
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Study Overview
Official Title:
None
Status:
UNKNOWN
Status Verified Date:
2013-06
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
DC
Brief Summary:
Pancreatic cancer is the second most frequent gastrointestinal malignancy The overall survival is dismal Especially for advanced pancreatic cancer the conventional approaches are typically not curative and provide only minor increases in survivals in most cases Dendritic cells DCs are powerful antigen-presenting cells APCs that play a pivotal role in the initiation programming and regulation of tumor-specific immune responses Isolated DCs loaded with tumor antigen ex vivo and administered as a cellular vaccine have been found to induce protective and therapeutic anti-tumor immunity in experimental animals Some clinical trials of DC vaccination for cancer patients have shown the induction of anti-tumor immune responses and tumor regression Endoscopic ultrasound EUS is an established technique for the diagnosis and staging of pancreatic cancer Endoscopic ultrasound guided fine-needle direct injection of dendritic cells vaccination into pancreatic tumors may be a promising treatment modalityTherefore The purpose of the study is to evaluate the efficacy and safety of endoscopic ultrasound guided fine-needle injection of DCs vaccination into advanced pancreatic cancer
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None