Ignite Creation Date:
2024-05-06 @ 1:43 AM
Last Modification Date:
2024-10-26 @ 11:08 AM
Study NCT ID:
NCT01884168
Status:
COMPLETED
Last Update Posted:
2024-02-07
First Post:
2013-06-19
Brief Title:
Study of Gene Expression Profiling and Immunological Mechanism Affects the Response of Immunotherapy
Sponsor:
Capital Medical University
Organization:
Capital Medical University
Study Overview
Official Title:
Gene Expression Profiling and Immunological Mechanism Affects the Response of Malignant Cavity Effusion Towards DC-CIK Immunotherapy
Status:
COMPLETED
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To investigate gene expression profile and immunological associated analysis relating to immunotherapy response of patients with malignant tumor presenting malignant cavity effusion after DC-CIK immunotherapy
Detailed Description:
1 The patients with malignant cavity effusion are treated with dendritic cells DC plus cytokine induced killer cells CIK locally
2 Malignant cavity effusion from cancer patients is obtained through puncture and is centrifugalized to get supernatant fluid and enrich cancer cells before and after the therapy
3 The enriched cancer cells which are flash frozen as well as the supernatant are stored at -80C until processing
4 The T-Cell ReceptorB-Cell Receptor gene expression in cavity effusion is detected by micro-array to explore the mechanism that DC-CIK immunotherapy controls the malignant cavity effusion
5 Statistical analysis is performed using unsupervised hierarchical cluster
2 Malignant cavity effusion from cancer patients is obtained through puncture and is centrifugalized to get supernatant fluid and enrich cancer cells before and after the therapy
3 The enriched cancer cells which are flash frozen as well as the supernatant are stored at -80C until processing
4 The T-Cell ReceptorB-Cell Receptor gene expression in cavity effusion is detected by micro-array to explore the mechanism that DC-CIK immunotherapy controls the malignant cavity effusion
5 Statistical analysis is performed using unsupervised hierarchical cluster
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None