Ignite Creation Date:
2024-05-06 @ 1:42 AM
Last Modification Date:
2024-10-26 @ 11:08 AM
Study NCT ID:
NCT01877590
Status:
COMPLETED
Last Update Posted:
2015-08-21
First Post:
2013-06-11
Brief Title:
Alpha-lipoic Acid Reduces Left Ventricular Mass in Normotensive Type 2 Diabetic Patients With Coronary Artery Disease
Sponsor:
Wuhan General Hospital of Guangzhou Military Command
Organization:
Wuhan General Hospital of Guangzhou Military Command
Study Overview
Official Title:
Alpha-lipoic Acid Reduces Left Ventricular Mass in Normotensive Type 2 Diabetic Patients With Coronary Artery Disease
Status:
COMPLETED
Status Verified Date:
2015-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Cardiovascular complications account for the highest mortality in type 2 diabetic patients mainly due to coronary artery disease CAD Most of the attention in treating CAD in type 2 diabetes is understandably directed toward treating coronary artery conditions However there are other treatable culprits in these patients
Left ventricular hypertrophy LVH is widespread in type 2 diabetic patients with CAD even in the absence of hypertension It is a strong predictor of cardiovascular events and all-cause mortality Regression of LVH has been associated with an improved prognosis independent of change in blood pressure BP Therefore cardiovascular events and mortality in type 2 diabetes with CAD might will be reduced if the investigators can find novel therapies to regress LVH
Alpha-lipoic acid reduces oxidative stress which then regresses LVH Alpha-lipoic acid can improve endothelial function in diabetic conditions Hence the main aim of this study was to assess whether alpha-lipoic acid could regress LVM in type 2 diabetic patients with CAD
Left ventricular hypertrophy LVH is widespread in type 2 diabetic patients with CAD even in the absence of hypertension It is a strong predictor of cardiovascular events and all-cause mortality Regression of LVH has been associated with an improved prognosis independent of change in blood pressure BP Therefore cardiovascular events and mortality in type 2 diabetes with CAD might will be reduced if the investigators can find novel therapies to regress LVH
Alpha-lipoic acid reduces oxidative stress which then regresses LVH Alpha-lipoic acid can improve endothelial function in diabetic conditions Hence the main aim of this study was to assess whether alpha-lipoic acid could regress LVM in type 2 diabetic patients with CAD
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None