Ignite Creation Date:
2024-05-05 @ 11:48 AM
Last Modification Date:
2024-10-26 @ 9:13 AM
Study NCT ID:
NCT00137254
Status:
COMPLETED
Last Update Posted:
2012-04-12
First Post:
2005-08-25
Brief Title:
Insulin on Post Burn Hypermetabolism
Sponsor:
United States Army Institute of Surgical Research
Organization:
United States Army Institute of Surgical Research
Study Overview
Official Title:
Effects of Insulin on Post Burn Hypermetabolism
Status:
COMPLETED
Status Verified Date:
2012-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to examine the effects of insulin on helping burn patients recover faster from their burns
Detailed Description:
Severe injuries produce profound hypermetabolic stress responses which cause severe loss of lean body mass and muscle wasting immunologic compromise slowed wound healing and related bone loss all which contribute to increased morbidity mortality and prolonged recovery from injury The results of hypermetabolism persist for weeks to months depending on the severity of the insult Massive burns can cause severe catabolism and are an excellent model to study the general effects of injury on protein metabolism Severe burns are characterized by dramatic increases in energy utilization and alterations in the metabolism of carbohydrates fat and protein
Insulin treatment improves net protein synthesis in the severely burned principally through improved muscle protein synthesis Although controversy exist as to whether insulin is effective as an anabolic hormone through increasing protein synthesis or decreasing protein breakdown we believe that consideration of the methods and experimental protocols used in the various studies bear consideration when evaluating this topic
Insulin treatment improves net protein synthesis in the severely burned principally through improved muscle protein synthesis Although controversy exist as to whether insulin is effective as an anabolic hormone through increasing protein synthesis or decreasing protein breakdown we believe that consideration of the methods and experimental protocols used in the various studies bear consideration when evaluating this topic
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| NIH RO-1 GM063120-02 | None | None | None |