Ignite Creation Date:
2024-05-05 @ 10:17 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005531
Status:
COMPLETED
Last Update Posted:
2016-02-18
First Post:
2000-05-25
Brief Title:
Genetic Epidemiology of Sarcoidosis
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2004-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To determine if hereditary susceptibility predisposes African Americans to sarcoidosis and to identify sarcoidosis susceptibility genes in African Americans
Detailed Description:
BACKGROUND
Sarcoidosis is a multisystem granulomatous inflammatory disease of unknown etiology Hereditary susceptibility to sarcoidosis is suggested by reports of familial clustering and a higher prevalence in certain ethnic groups particularly African-Americans Over four hundred kindreds been reported in the medical literature and these investigators have recently described 101 families and shown that African Americans have a higher prevalence rate of familial sarcoidosis than Caucasians 19 percent vs 5 percent The reasons why sarcoidosis clusters in families or the role of genetic factors in this disease are not known
DESIGN NARRATIVE
The study was carried out in African American families ascertained through 400 African American sarcoidosis patients evaluated at the Henry Ford Health System They were tested for association of sarcoidosis with markers for candidate genes using the affected family-based control method and tested for possible environmental risk factors and genetic mechanisms of disease transmission by performing a segregation analysis in African American families
A strong association of one or more of the candidate genes with sarcoidosis or an indication of major gene segregation for the disease provided the basis for future linkage studies Investigating the hereditary susceptibility of sarcoidosis was best done in African Americans because of the greater severity and occurrence of disease in this population Once the reasons for familial aggregation of sarcoidosis are determined the etiology of this disease will be better understood and it should be possible to design new approaches to prevention and treatment
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS recor
Sarcoidosis is a multisystem granulomatous inflammatory disease of unknown etiology Hereditary susceptibility to sarcoidosis is suggested by reports of familial clustering and a higher prevalence in certain ethnic groups particularly African-Americans Over four hundred kindreds been reported in the medical literature and these investigators have recently described 101 families and shown that African Americans have a higher prevalence rate of familial sarcoidosis than Caucasians 19 percent vs 5 percent The reasons why sarcoidosis clusters in families or the role of genetic factors in this disease are not known
DESIGN NARRATIVE
The study was carried out in African American families ascertained through 400 African American sarcoidosis patients evaluated at the Henry Ford Health System They were tested for association of sarcoidosis with markers for candidate genes using the affected family-based control method and tested for possible environmental risk factors and genetic mechanisms of disease transmission by performing a segregation analysis in African American families
A strong association of one or more of the candidate genes with sarcoidosis or an indication of major gene segregation for the disease provided the basis for future linkage studies Investigating the hereditary susceptibility of sarcoidosis was best done in African Americans because of the greater severity and occurrence of disease in this population Once the reasons for familial aggregation of sarcoidosis are determined the etiology of this disease will be better understood and it should be possible to design new approaches to prevention and treatment
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS recor
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL054306 | NIH | None | httpsreporternihgovquickSearchR01HL054306 |