Ignite Creation Date:
2024-05-06 @ 1:41 AM
Last Modification Date:
2024-10-26 @ 11:08 AM
Study NCT ID:
NCT01877603
Status:
COMPLETED
Last Update Posted:
2015-06-16
First Post:
2013-06-11
Brief Title:
The Relation Between Plasma Irisin Level and Endothelial Dysfunction in Type 2 Diabetes
Sponsor:
Wuhan General Hospital of Guangzhou Military Command
Organization:
Wuhan General Hospital of Guangzhou Military Command
Study Overview
Official Title:
The Relation Between Plasma Irisin Level and Endothelial Dysfunction in Type 2 Diabetes
Status:
COMPLETED
Status Verified Date:
2015-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Irisin is a signaling protein that is released into the blood from skeletal muscle after proteolysis of the membrane protein FNDC5 FNDC5 encoded by the Fndc5 gene Irisin activity on subcutaneous white adipose tissue both in culture and in vivo stimulated UCP1 expression and induction of brown adipocytes in white adipose tissue depots a process known as white fat browning Irisin increases total energy expenditure in animal models and irisin expression in mice fed a high fat diet resulted in a significant improvement in glucose tolerance and a reduction in fasting insulin levels Collectively these data suggest that decreased serum irisin levels may be associated with the development of insulin resistance and Type 2 diabetes Indeed some studies showed that irisin levels were decreased in newly diagnosed Type 2 diabetes
Endothelial dysfunction is an early physiological event in atherosclerosis However to date no data are available on the relationship between circulating irisin and endothelial dysfunction in diabetes Therefore the investigators hypothesized that circulating irisin level is associated with endothelial dysfunction
Endothelial dysfunction is an early physiological event in atherosclerosis However to date no data are available on the relationship between circulating irisin and endothelial dysfunction in diabetes Therefore the investigators hypothesized that circulating irisin level is associated with endothelial dysfunction
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None