Ignite Creation Date:
2024-05-06 @ 1:41 AM
Last Modification Date:
2024-10-26 @ 11:08 AM
Study NCT ID:
NCT01871935
Status:
UNKNOWN
Last Update Posted:
2014-01-31
First Post:
2013-05-30
Brief Title:
Atropine Effects in Anaesthesia With Sufentanil vs Remifentanil
Sponsor:
University Medical Center Groningen
Organization:
University Medical Center Groningen
Study Overview
Official Title:
Comparison of the Effects of Atropine on Haemodynamics and Tissue Oxygenation in Anaesthesia With Propofol and Sufentanil Versus Propofol and Remifentanil
Status:
UNKNOWN
Status Verified Date:
2014-01
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Induction of general anaesthesia with a combination of opiates and hypnotics often induces vasodilation resulting in several haemodynamic effects such as a decrease in blood pressure MAP heart rate HR and cardiac output CO This haemodynamic suppression may jeopardize tissue oxygenation particularly cerebral oxygenation Previous research of the investigators group has revealed that atropine has an exceptionally beneficial effect on the determinants of tissue oxygen delivery as well as on tissue oxygenation The investigators have demonstrated a significant and clinically relevant increase in CO and cerebral tissue oxygenation SctO2 for a desired increase in MAP This is in steep contrast with the more usual clinical practice of administrating classical vasoactive medication such as phenylephrine or norepinephrine since the two latter have an even negative effect on CO and SctO2 In previous research the investigators used standardized target controlled propofolremifentanil infusions for induction and maintenance of anaesthesia It is known that remifentanil has more intense haemodynamic side-effects compared to other opiates such as fentanyl sufentanil or alfentanil This raises the question whether the beneficial effect of atropine is restricted to propofolremifentanil anaesthesia or if this is equally valid during anaesthesia of propofol combined with other opiates such as sufentanil
Patients undergoing off-pump coronary artery bypass grafting CABG require a long and deep general anaesthesia which is usually performed with the combination of drugs as mentioned above Because these patients often experience severe haemodynamic fluctuations they need to be closely monitored
Patients undergoing off-pump coronary artery bypass grafting CABG require a long and deep general anaesthesia which is usually performed with the combination of drugs as mentioned above Because these patients often experience severe haemodynamic fluctuations they need to be closely monitored
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None