Ignite Creation Date:
2024-05-06 @ 1:40 AM
Last Modification Date:
2024-10-26 @ 11:07 AM
Study NCT ID:
NCT01862731
Status:
RECRUITING
Last Update Posted:
2024-05-16
First Post:
2013-05-23
Brief Title:
Muscle Strength Loss and Its Effect on Knee Cap Motion in Volunteers With Anterior Knee Pain
Sponsor:
National Institutes of Health Clinical Center CC
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Vasti Control of Patellofemoral Kinematics in Patients With Chronic Patellofemoral Pain
Status:
RECRUITING
Status Verified Date:
2024-07-29
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Background
- Researchers are interested in how the muscles affect the movement of the knee cap These muscles may be related to different kinds of knee pain that are not caused by an injury or a disease Imaging studies such as magnetic resonance imaging MRI can be used to look at these muscles To study these muscles and how they move researchers will use MRI to look at healthy individuals and individuals with knee cap pain
Objectives
- To study how changes to the muscles around the knee can influence knee pain
Eligibility
Individuals between 18 to 55 years of age who have knee cap pain that cannot be explained by a specific injury or disease
Healthy volunteers between 18 and 55 years of age
Design
Participants will be screened with a physical exam and medical history
This study requires two visits Each visit will use standard MRI sequences to take images of the knee in motion and at rest
On the first visit the MRI scan will look at the knee in its natural state Participants will move the knee up and down for 1 to 3 minutes at a time during the scan
On the second visit a local anesthetic agent will be injected into the muscle of the thigh The anesthetic will block this muscle from generating force for 2 or 3 hours Participants will move the knee up and down for 1 to 3 minutes at a time during the MRI scan
- Researchers are interested in how the muscles affect the movement of the knee cap These muscles may be related to different kinds of knee pain that are not caused by an injury or a disease Imaging studies such as magnetic resonance imaging MRI can be used to look at these muscles To study these muscles and how they move researchers will use MRI to look at healthy individuals and individuals with knee cap pain
Objectives
- To study how changes to the muscles around the knee can influence knee pain
Eligibility
Individuals between 18 to 55 years of age who have knee cap pain that cannot be explained by a specific injury or disease
Healthy volunteers between 18 and 55 years of age
Design
Participants will be screened with a physical exam and medical history
This study requires two visits Each visit will use standard MRI sequences to take images of the knee in motion and at rest
On the first visit the MRI scan will look at the knee in its natural state Participants will move the knee up and down for 1 to 3 minutes at a time during the scan
On the second visit a local anesthetic agent will be injected into the muscle of the thigh The anesthetic will block this muscle from generating force for 2 or 3 hours Participants will move the knee up and down for 1 to 3 minutes at a time during the MRI scan
Detailed Description:
Chronic idiopathic patellofemoral pain a potential precursor to osteoarthritis is one of the most common problems of the knee It is characterized by anterior knee pain that is aggravated by deep knee flexion prolonged sitting and repetitive flexionextension The most widely accepted theory in regards to the source of this pain is that a force imbalance around the knee leads to static patellofemoral malalignment and dynamic patellofemoral maltracking In turn this malalignment and maltracking leads to elevated joint contact stresses which ultimately leads to patellofemoral pain Current understanding of patellofemoral maltracking is typically focused on static 2D alignment lateral tilt and displacement Yet patellofemoral pain is most often exacerbated during dynamic events and the patella has complete six degrees of freedom in its movement More recent studies have been able to quantify patellofemoral kinematics during volitional dynamic tasks and demonstrate that the maltracking problem is more complex than originally postulated Specifically in patients with patellofemoral pain altered kinematics are not limited to excessive patellar lateral translation and tilt but include excessive patellar superior translation along with excessive flexion and valgus rotations Flexion and valgus are sagittal and coronal plane rotations that cause the superior pole of the patella to shift anteriorly and medially respectively Recent work has shown that altered force balance around the knee can indeed lead to maltracking However the question remains whether correcting an existing force imbalance around the knee can normalize patellar kinematics andor reduce pain The purpose of this study is to determine how temporary iatrogenic loss of force in the vastus lateralis muscle alters the aberrant patellar kinematics in subjects with chronic idiopathic patellofemoral pain
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 13-CC-0099 | None | None | None |