Ignite Creation Date:
2024-05-06 @ 1:39 AM
Last Modification Date:
2024-10-26 @ 11:07 AM
Study NCT ID:
NCT01860586
Status:
COMPLETED
Last Update Posted:
2017-04-17
First Post:
2013-05-20
Brief Title:
Eye Injections of Bevacizumab for Lowering Risk of Scar Tissue in the Retina and Repeated Retinal Detachment
Sponsor:
Wills Eye
Organization:
Wills Eye
Study Overview
Official Title:
A Prospective Pilot Study Evaluating the Effect of Intravitreal Injection of Bevacizumab on Recurrent Retinal Detachment Due to Proliferative Vitreoretinopathy
Status:
COMPLETED
Status Verified Date:
2017-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to examine the effects of a drug called bevacizumab Avastin on the rates of recurrent retinal detachment and scar tissue formation
Detailed Description:
Proliferative vitreoretinopathy PVR remains the most significant obstacle to successful retinal detachment RD repair accounting for up to 75 of all primary surgical failures Characterized by the proliferation of cells on the preretinal or subretinal surface PVR ultimately leads to contraction foreshortening and ultimately recurrent detachment of the retina Several PVR risk factors have been identified including pre-existing uveitis large retinal tears multiple retinal breaks detachments involving greater than two quadrants of the retina vitreous hemorrhage and choroidal detachment Given the absence of a proven medical therapy for PVR and prior studies establishing VEGF as a potential therapeutic target further clinical evaluation is warranted Herein we report outcomes of a prospective non-randomized historical-control pilot study evaluating the effect of serial intrasilicone oil bevacizumab injections on outcomes of PVR-related RD repair
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| MARPVR2013 | OTHER | Mid Atlantic Retina | None |