Ignite Creation Date:
2025-12-25 @ 5:03 AM
Ignite Modification Date:
2025-12-26 @ 4:05 AM
Study NCT ID:
NCT05640518
Status:
UNKNOWN
Last Update Posted:
2023-01-25
First Post:
2022-10-20
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
External Validation of the VExUS Score for the Prediction of Acute Renal Failure in Cardiac Surgery
Sponsor:
University Hospital, Grenoble
Organization:
Study Overview
Official Title:
External Validation of the VExUS Score for the Prediction of Acute Renal Failure in Cardiac Surgery
Status:
UNKNOWN
Status Verified Date:
2022-10
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
ValiVexus
Brief Summary:
Acute renal failure is a frequent complication associated with significant morbidity and mortality in postoperative cardiac surgery.
The VExUS (Venous Excess UltraSound grading system) score was created to qualitatively assess this venous congestion, based on ultrasound data from patients obtained post operatively in cardiac surgery. These data included: inferior vena cava diameter, Doppler flow of the suprahepatic veins, portal trunk and renal veins.
This score is predictive of the onset of acute renal failure in the first 3 days after surgery.
The VExUS score has not been validated in an external and prospective way in cardiac surgery.
The VExUS (Venous Excess UltraSound grading system) score was created to qualitatively assess this venous congestion, based on ultrasound data from patients obtained post operatively in cardiac surgery. These data included: inferior vena cava diameter, Doppler flow of the suprahepatic veins, portal trunk and renal veins.
This score is predictive of the onset of acute renal failure in the first 3 days after surgery.
The VExUS score has not been validated in an external and prospective way in cardiac surgery.
Detailed Description:
Acute renal failure is a frequent complication associated with significant morbidity and mortality in postoperative cardiac surgery.
The pathophysiology in this context is complex, poorly understood and the causes are multiple: underlying nephropathy, intra- or postoperative haemodynamic instability, the use of an extracorporeal circulation, inflammation, etc.
One of the other possible etiologies is venous congestion. This may be due to volume overload and/or isolated global or right heart dysfunction.
Early treatment could prevent the onset of ARF or reduce its consequences, hence the importance of being able to predict its onset.
The VExUS (Venous Excess UltraSound grading system) score was created to qualitatively assess this venous congestion, based on ultrasound data from patients obtained post operatively in cardiac surgery. These data included: inferior vena cava diameter, Doppler flow of the suprahepatic veins, portal trunk and renal veins.
This score is predictive of the onset of acute renal failure in the first 3 days after surgery.
The VExUS score has not been validated in an external and prospective way in cardiac surgery.
The pathophysiology in this context is complex, poorly understood and the causes are multiple: underlying nephropathy, intra- or postoperative haemodynamic instability, the use of an extracorporeal circulation, inflammation, etc.
One of the other possible etiologies is venous congestion. This may be due to volume overload and/or isolated global or right heart dysfunction.
Early treatment could prevent the onset of ARF or reduce its consequences, hence the importance of being able to predict its onset.
The VExUS (Venous Excess UltraSound grading system) score was created to qualitatively assess this venous congestion, based on ultrasound data from patients obtained post operatively in cardiac surgery. These data included: inferior vena cava diameter, Doppler flow of the suprahepatic veins, portal trunk and renal veins.
This score is predictive of the onset of acute renal failure in the first 3 days after surgery.
The VExUS score has not been validated in an external and prospective way in cardiac surgery.
Study Oversight
Has Oversight DMC:
False
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?: