Ignite Creation Date:
2024-05-05 @ 11:47 AM
Last Modification Date:
2024-10-26 @ 9:13 AM
Study NCT ID:
NCT00130585
Status:
COMPLETED
Last Update Posted:
2005-10-04
First Post:
2005-08-12
Brief Title:
Bioavailability of Folate From a Mixed Diet Using a Stable Isotope Method
Sponsor:
Wageningen Centre for Food Sciences
Organization:
Wageningen University
Study Overview
Official Title:
The Relative Bioavailability of Folate From a Mixed Diet Compared to Synthetic Folic Acid Using a Stable Isotope Method
Status:
COMPLETED
Status Verified Date:
2005-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The main objectives of this project are
1 to determine the relative bioavailability of dietary folate from a total diet compared with synthetic folic acid and
2 to determine the bioavailability with a higher precision than previous methods
The hypothesis is that the bioavailability of dietary folate within a confidence interval of -20 can be estimated
1 to determine the relative bioavailability of dietary folate from a total diet compared with synthetic folic acid and
2 to determine the bioavailability with a higher precision than previous methods
The hypothesis is that the bioavailability of dietary folate within a confidence interval of -20 can be estimated
Detailed Description:
Folate plays a role in the prevention of certain birth defects and possibly also in prevention of neurocognitive diseases cancer and cardiovascular disease The proportion of dietary folate that is absorbed and becomes available for metabolic processes in the body has been estimated between 30 and 98 but an accurate figure is lacking Since subjects generally differ a lot in their folate or homocysteine response upon a change in dietary folate intake the between-person variability in these responses is high Therefore bioavailability estimates derived from these responses have large confidence intervals With this trial the researchers want to determine folate bioavailability with a higher precision than previous trials A good estimate of folate bioavailability from the general diet is necessary to construct reliable dietary reference intakes for folate
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None