Ignite Creation Date:
2024-05-05 @ 11:47 AM
Last Modification Date:
2024-10-26 @ 9:13 AM
Study NCT ID:
NCT00134381
Status:
TERMINATED
Last Update Posted:
2017-09-06
First Post:
2005-08-22
Brief Title:
Green Tea and Ultraviolet Light-induced Skin Damage
Sponsor:
Rutgers The State University of New Jersey
Organization:
Rutgers The State University of New Jersey
Study Overview
Official Title:
The Effects of Topically Applied Constituents of Green Tea on UV Induced Increase in p53 and Apoptotic Markers in the Skin of Human Volunteers
Status:
TERMINATED
Status Verified Date:
2017-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Principal Investigator left institution before study could complete
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to investigate whether topically applied constituents of green tea caffeine or --epigallocatechin gallate EGCG have a protective effect on skin exposed to ultraviolet light UV
Detailed Description:
The purpose of this study is to investigate if topically applied constituents of green tea caffeine or - - epigallocatechin gallate EGCG have a protective effect on skin exposed to ultraviolet light UV In the double-blinded study all subjects will receive 311 nanometer UVB light at a dose that is 05-15X their individual minimal erythema dose MED One part of the experiment will involve applying a topical natural product caffeine or EGCG and placebo to bilateral symmetric sites The natural product and the placebo will be applied immediately after and at 12 hour 1 hour 2 hours 4 hours 6 hours 8 hours 24 hours 25 hours and 27 hours after exposure to a 05-15 MED dose of UV light Another part of the study involves performing skin biopsies One will be done prior to UVB exposure 2 will be done at 24 hours and 2 more will be done at 48 hours
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None