Ignite Creation Date:
2024-05-05 @ 11:47 AM
Last Modification Date:
2024-10-26 @ 9:13 AM
Study NCT ID:
NCT00135772
Status:
COMPLETED
Last Update Posted:
2017-01-12
First Post:
2005-08-23
Brief Title:
Nicotine and Cotinine Levels in Smokers With Schizophrenia and Schizoaffective Disorder - 2
Sponsor:
National Institute on Drug Abuse NIDA
Organization:
National Institute on Drug Abuse NIDA
Study Overview
Official Title:
Nicotine and Cotinine Levels in Smokers With Schizophrenia and Schizoaffective Disorder
Status:
COMPLETED
Status Verified Date:
2008-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Nicotine dependence is very common among individuals with schizophrenia and schizoaffective disorder Cotinine is a chemical that is made by the body from nicotine Measuring levels of nicotine and cotinine is an accurate way to determine how much cigarette smoke enters a persons body The purpose of this study is to measure nicotine and cotinine levels in smokers with schizophrenia or schizoaffective disorder to determine if such individuals absorb more nicotine per cigarette than smokers without schizophrenia-related disorders
Detailed Description:
Schizophrenic individuals have higher urinary cotinine levels compared to non-schizophrenic individuals with a similar smoking history This suggests that schizophrenic individuals may absorb higher doses of nicotine The purpose of this study is to determine whether smokers with schizophrenia or schizoaffective disorder have higher serum nicotine and cotinine levels in comparison to smokers without schizophrenic-related disorders
This observational case-control study will enroll 150 participants of which 100 will be smokers with schizophrenic-related disorders and 50 will be smokers without a mental illness Upon completing baseline assessments participants will smoke a single cigarette Approximately two minutes following 3 to 4 ounces of blood will be analyzed for nicotine and cotinine levels An expired carbon monoxide reading will also be measured This measurement correlates with the amount of smoke inhalation Individual participant studies will be completed in 1 to 2 hour-long sessions
This observational case-control study will enroll 150 participants of which 100 will be smokers with schizophrenic-related disorders and 50 will be smokers without a mental illness Upon completing baseline assessments participants will smoke a single cigarette Approximately two minutes following 3 to 4 ounces of blood will be analyzed for nicotine and cotinine levels An expired carbon monoxide reading will also be measured This measurement correlates with the amount of smoke inhalation Individual participant studies will be completed in 1 to 2 hour-long sessions
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| DPMC | None | None | None |
| K23-14009-2 | None | None | None |