Ignite Creation Date:
2024-05-06 @ 1:35 AM
Last Modification Date:
2024-10-26 @ 11:06 AM
Study NCT ID:
NCT01843959
Status:
COMPLETED
Last Update Posted:
2021-10-13
First Post:
2013-04-25
Brief Title:
Abu Dhabi Diabetes and Obesity Study
Sponsor:
Imperial College London Diabetes Centre
Organization:
Imperial College London Diabetes Centre
Study Overview
Official Title:
Abu Dhabi Diabetes and Obesity Study ADOS - A Study on the Aetiology and Associated Risk Factors of Patients With ObesityDiabetes Within the Emirati Population
Status:
COMPLETED
Status Verified Date:
2021-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
A cross-sectional study investigating the aetiology mechanisms and associated complications contributing to obesity and diabetes within the UAE population The study will be carried out in two main sample populations children and adults and characterized by the occurrence of obesity and diabetes The main samples will then be divided into a subgroup for metabolomic analysis Patients will be recruited from the Imperial College London Diabetes Centre The study is aimed at elucidating the various factors that have an impact or may influence obesity and diabetes in the Emirati population
Detailed Description:
Obesity and Type 2 diabetes T2DM have been regarded as global epidemics in developed countries and more recently in developing nations Obesity a T2DM risk factor and T2DM present significant health risks as individual diseases and substantial risks in individuals with both complications Deepa Nath 2006 The UAE and USA have a similar prevalence of obesity 36 and 357 respectively Interestingly the percentage of the population with T2DM between the two groups differs significantly 25 and 87 respectively The rate of T2DM in the Emirati population is 29 fold higher than in the US This suggests an altered inter relationship between obesity and T2DM One hypothesis that could explain such a variation is differences in body metabolism and central adiposity between the two populations This will be assessed by measuring cardiometabolic risk factors central adiposity and metabolomics Analysis of the metabolomic profiles may help define the risk factors associated with diabetes and differences in metabolic activity between various ethnicities
Another area of ample interest is the advanced glycation end-products AGEs metabolic pathways Pietropaoli D 2012 AGEs are formed at an increased rate in diabetes and have a number of detrimental effects such as retinopathy nephropathy and atherosclerosis Melpomeni Peppa 2003 As such determining the core mechanisms that result in metabolic and cardiovascular dysfunction will aid in identifying and developing therapeutic targets which may in turn alleviate the deleterious effects of respective disorders such as diabetes
The aetiology of diabetes is complex However adenovirus 36 has been shown to play a significant role in obesity and diabetes As such analysis of ADV-36 occurrence within the Emirati population may provide insight into a novel obesity and diabetes risk factor and could further clarify the relationship between obesity and T2DM
This study may provide evidence that clarifies how obesity can result in T2DM and why this occurrence is more predominant in the Emirati population In addition the assessment of AGEs within the population ranging from people with diabetes and obesity to healthy individual may provide insight into potential therapeutic targets thereby improving overall heath in the population Finally the data may improve our knowledge of new risk factors such as ADV-36 and their subsequent effects on diabetes
Another area of ample interest is the advanced glycation end-products AGEs metabolic pathways Pietropaoli D 2012 AGEs are formed at an increased rate in diabetes and have a number of detrimental effects such as retinopathy nephropathy and atherosclerosis Melpomeni Peppa 2003 As such determining the core mechanisms that result in metabolic and cardiovascular dysfunction will aid in identifying and developing therapeutic targets which may in turn alleviate the deleterious effects of respective disorders such as diabetes
The aetiology of diabetes is complex However adenovirus 36 has been shown to play a significant role in obesity and diabetes As such analysis of ADV-36 occurrence within the Emirati population may provide insight into a novel obesity and diabetes risk factor and could further clarify the relationship between obesity and T2DM
This study may provide evidence that clarifies how obesity can result in T2DM and why this occurrence is more predominant in the Emirati population In addition the assessment of AGEs within the population ranging from people with diabetes and obesity to healthy individual may provide insight into potential therapeutic targets thereby improving overall heath in the population Finally the data may improve our knowledge of new risk factors such as ADV-36 and their subsequent effects on diabetes
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None