Ignite Creation Date:
2024-05-05 @ 9:36 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005346
Status:
COMPLETED
Last Update Posted:
2016-05-13
First Post:
2000-05-25
Brief Title:
Mechanisms Underlying Abnormal Ambulatory BP Patterns
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2001-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To understand the mechanisms underlying sodium-dependent blood pressure control and to determine the consequences thereof
Detailed Description:
BACKGROUND
The blood pressure of a significant percentage of the hypertensive population and the normotensive population at a high risk for the development of hypertension Blacks and older individuals is sodium salt-dependent That is to say increasing the intake of salt will increase blood pressure in these individuals conversely and more importantly decreasing the intake of salt will reduce blood pressure
DESIGN NARRATIVE
The investigators believed that the mechanisms responsible for sodium-dependent blood pressure were only indirectly linked to race sex and age Their research was consistent with the hypothesis that sodium-dependent blood pressure control resulted from decreased responsiveness of the renal and adrenal blood pressure regulatory systems This produced abnormal daily blood pressure patterns with reduced fluctuation resulting in extended periods of increased blood pressure The increased cardiovascular load led to the early development of cardiovascular and renal disease including hypertension They tested this hypothesis by identifying high risk and normal risk subjects based on renal responses to sodium restriction The subjects were equal numbers of healthy males and females Blacks and whites between the ages of 55-70 years Using an innovative approach they then examined the influence of risk status on 24-hour patterns of blood pressure hormonal activity and sodium handling Finally they determined the clinical significance of the profiles by examining changes in cardiac and renal status at a two-year follow-up
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
The blood pressure of a significant percentage of the hypertensive population and the normotensive population at a high risk for the development of hypertension Blacks and older individuals is sodium salt-dependent That is to say increasing the intake of salt will increase blood pressure in these individuals conversely and more importantly decreasing the intake of salt will reduce blood pressure
DESIGN NARRATIVE
The investigators believed that the mechanisms responsible for sodium-dependent blood pressure were only indirectly linked to race sex and age Their research was consistent with the hypothesis that sodium-dependent blood pressure control resulted from decreased responsiveness of the renal and adrenal blood pressure regulatory systems This produced abnormal daily blood pressure patterns with reduced fluctuation resulting in extended periods of increased blood pressure The increased cardiovascular load led to the early development of cardiovascular and renal disease including hypertension They tested this hypothesis by identifying high risk and normal risk subjects based on renal responses to sodium restriction The subjects were equal numbers of healthy males and females Blacks and whites between the ages of 55-70 years Using an innovative approach they then examined the influence of risk status on 24-hour patterns of blood pressure hormonal activity and sodium handling Finally they determined the clinical significance of the profiles by examining changes in cardiac and renal status at a two-year follow-up
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL046177 | NIH | None | httpsreporternihgovquickSearchR01HL046177 |