Ignite Creation Date:
2024-05-06 @ 1:32 AM
Last Modification Date:
2024-10-26 @ 11:05 AM
Study NCT ID:
NCT01832701
Status:
COMPLETED
Last Update Posted:
2014-04-21
First Post:
2013-04-08
Brief Title:
Coffee Exercise and Oxidative Stress
Sponsor:
Société des Produits Nestlé SPN
Organization:
Société des Produits Nestlé SPN
Study Overview
Official Title:
Coffee and Oxidative Stress During Exercise in Healthy Humans
Status:
COMPLETED
Status Verified Date:
2014-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Coffee is one of the most widely consumed beverages It contains polyphenols chlorogenic acids and bioavailability of these bioactive compounds is now somewhat well understood In addition chlorogenic acids are known to be antioxidants in the cup but reliable evidence remains to be observed in vivo The objective of this trial is to understand if regular 14d coffee intake may be beneficial on biomarkers of oxidative damage measured in urine and plasma after an acute stress caused by exercise
Detailed Description:
Coffee is one of the most widely consumed beverages It contains polyphenols chlorogenic acids and bioavailability of these bioactive compounds is now somewhat well understood However even if chlorogenic acids are known to be antioxidants in the cup reliable evidence remains to be observed in vivo
After medical examination and approval subjects will undergo 2 periods of 21 days The first 7 days will consist of a dietary restriction to lower the polyphenols intake Then subjects will drink at random one of the three treatments for 14 days 4 cupsday Blood and urine samples will be collected throughout the study to evaluate in vivo effects on oxidative biomarkers Furthermore at day 21 subjects will undergo a physical regimen to increase acutely and transiently their oxidative damage Blood and urine samples collected throughout this challenge will allow us to evaluate the effect of coffee intake in reducing oxidative damage created by exercise compared to placebo
After medical examination and approval subjects will undergo 2 periods of 21 days The first 7 days will consist of a dietary restriction to lower the polyphenols intake Then subjects will drink at random one of the three treatments for 14 days 4 cupsday Blood and urine samples will be collected throughout the study to evaluate in vivo effects on oxidative biomarkers Furthermore at day 21 subjects will undergo a physical regimen to increase acutely and transiently their oxidative damage Blood and urine samples collected throughout this challenge will allow us to evaluate the effect of coffee intake in reducing oxidative damage created by exercise compared to placebo
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None