Ignite Creation Date:
2024-05-06 @ 1:30 AM
Last Modification Date:
2024-10-26 @ 11:05 AM
Study NCT ID:
NCT01824680
Status:
SUSPENDED
Last Update Posted:
2013-04-05
First Post:
2013-02-28
Brief Title:
Effect of a Physical Activity Program on the Hormonal Regulation of Food Intake
Sponsor:
University Hospital Clermont-Ferrand
Organization:
University Hospital Clermont-Ferrand
Study Overview
Official Title:
Effect of a 3 Months Physical Activity Program on the Hormonal Regulation of Food Intake by Intense Physical Activity in Overweight Adolescents
Status:
SUSPENDED
Status Verified Date:
2013-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
APHRO
Brief Summary:
The primary purpose of this protocol is to assess the hormonal regulation of satiety by an intense exercise before and after a 3 month physical activity program Hormones assessed are leptin grhélin Cholecystokinin Glucagon-Like-Peptid-1 GLP-1 PYY
It is well known that in overweight adults and children also an intense physical exercise diminish the food intake relatively to the total energy expenditure and this effect is persistent after a 6 weeks physical activity program
Our hypothesis are a diminution of food intake after the intense physical exercise and a persistent diminution of food intake after the 3 month physical activity program an augmentation of levels of GLP-1 and PYY during the intense exercise before and after the physical activity program a diminution of the level of GLP-1 and leptin before and after the physical activity program
It is well known that in overweight adults and children also an intense physical exercise diminish the food intake relatively to the total energy expenditure and this effect is persistent after a 6 weeks physical activity program
Our hypothesis are a diminution of food intake after the intense physical exercise and a persistent diminution of food intake after the 3 month physical activity program an augmentation of levels of GLP-1 and PYY during the intense exercise before and after the physical activity program a diminution of the level of GLP-1 and leptin before and after the physical activity program
Detailed Description:
There is two sequences one before and one after the physical activity program Each sequence contains one rest session and one exercise session
Each session contains blood sample at regular interval Leptin Ghrélin CCK PYY GLP-1 a sleeping assessment Pittsburg scale an assessment of hunger sensations at regular interval an assessment of food intake in a ad libitum lunch and in the diner indirectly by the SUVIMAX tool
During the rest session
Blood samples assessment of hunger sensation assessment of food intake are realized during the morning Physical condition VO2 max DEXA and muscular test insulin-sensibility lipid profile are also assessed
During the exercise session it is identical to the first session but an intense exercise of 40 minutes is realized at 70 of the patients VO2 max The peripherical blood output is measured by a non-invasive method the Near-Infra-Red-Spectroscopy during the exercise
The 3-months-physical activity program there is 4 sessions of 30 minutes and 2 sessions of 1 hour per week Most of exercises sessions are realized at home but one 1-hour session per week is controled with a sports educator
Each session contains blood sample at regular interval Leptin Ghrélin CCK PYY GLP-1 a sleeping assessment Pittsburg scale an assessment of hunger sensations at regular interval an assessment of food intake in a ad libitum lunch and in the diner indirectly by the SUVIMAX tool
During the rest session
Blood samples assessment of hunger sensation assessment of food intake are realized during the morning Physical condition VO2 max DEXA and muscular test insulin-sensibility lipid profile are also assessed
During the exercise session it is identical to the first session but an intense exercise of 40 minutes is realized at 70 of the patients VO2 max The peripherical blood output is measured by a non-invasive method the Near-Infra-Red-Spectroscopy during the exercise
The 3-months-physical activity program there is 4 sessions of 30 minutes and 2 sessions of 1 hour per week Most of exercises sessions are realized at home but one 1-hour session per week is controled with a sports educator
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None