Ignite Creation Date:
2024-05-06 @ 1:29 AM
Last Modification Date:
2024-10-26 @ 11:05 AM
Study NCT ID:
NCT01829672
Status:
COMPLETED
Last Update Posted:
2017-07-11
First Post:
2013-04-09
Brief Title:
Non-invasive Diagnostics of Pulmonary Hypertension With Dual Energy Computed Tomography
Sponsor:
Medical University of Graz
Organization:
Medical University of Graz
Study Overview
Official Title:
Non-invasive Diagnostics of Pulmonary Hypertension With Dual Energy Computed Tomography - Prospective Study
Status:
COMPLETED
Status Verified Date:
2017-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of the study is to determine relevant hemodynamic parameters for the diagnostics of pulmonary arterial hypertension PAH by dynamic contrast enhanced dual-energy CT DE-CT In this prospective study the investigators validate DE-CT results of patients against hemodynamic parameters from right heart catheterisation and control the results by other clinical investigations The investigators expect that using this non-invasive method parameters relevant for the diagnosis of the patients with PAH like pulmonary blood volume blood flow and perfusion heterogeneity can be determined
Detailed Description:
Pulmonary arterial hypertension PAH is a rare life-threatening disease It is characterized by the elevation of pulmonary arterial pressure and pulmonary vascular resistance A remodeling of small pulmonary vessels characterized by the proliferation of the adventitia the hypertrophy of the media and fibrosis of the intima can be observed on the microscopic level
Non-invasive techniques for hemodynamic assessment and identification of early pulmonary vascular remodeling and pulmonary hypertension have a marked practical advantage as compared to invasive right heart catheterization however their accuracy and reliability is not well established
In the present study the investigators examine patients who are scheduled for a thorax CT with an additional dynamic contrast-enhanced DE-CT protocol and derive established parameters for the diagnosis of PAH as well as novel parameters from the CT scans These are compared to results from the right-heart catheterization and other investigations routinely carried out on these patients
Non-invasive techniques for hemodynamic assessment and identification of early pulmonary vascular remodeling and pulmonary hypertension have a marked practical advantage as compared to invasive right heart catheterization however their accuracy and reliability is not well established
In the present study the investigators examine patients who are scheduled for a thorax CT with an additional dynamic contrast-enhanced DE-CT protocol and derive established parameters for the diagnosis of PAH as well as novel parameters from the CT scans These are compared to results from the right-heart catheterization and other investigations routinely carried out on these patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None