Ignite Creation Date:
2024-05-05 @ 11:47 AM
Last Modification Date:
2024-10-26 @ 9:12 AM
Study NCT ID:
NCT00121446
Status:
COMPLETED
Last Update Posted:
2017-05-19
First Post:
2005-07-13
Brief Title:
Which Therapy for Acute Heart Attacks The WEST Study
Sponsor:
University of Alberta
Organization:
University of Alberta
Study Overview
Official Title:
Which Early ST Elevation Myocardial Infarction Therapy The WEST Study
Status:
COMPLETED
Status Verified Date:
2005-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In the setting of acute myocardial infarction heart attacks the principle objective of the WEST Study is to compare the impact on clinical outcomes of 3 different treatment strategies The first is using medical drug therapy alone with standard care The second strategy is identical medical drug therapy as the first group combined with early heart catheterization within 24 hours for angiography and if required intervention The third treatment strategy is direct admission within 3 hrs to the heart catheterization lab for angioplasty
WEST patients will be enrolled at first medical contact using emergency medical services eg ambulance if possible or through Emergency Departments in participating health care facilities
WEST patients will be enrolled at first medical contact using emergency medical services eg ambulance if possible or through Emergency Departments in participating health care facilities
Detailed Description:
The principal objective of WEST is to compare the impact on clinical outcomes of the following three treatment groups defined as Group A optimal pharmacologic therapy prompt administration of tenecteplase TNKase and enoxaparin at the earliest point of medical contact with usual post MI care Group B an identical pharmacological reperfusion strategy followed by an early invasive strategy including timely mechanical intervention Group C timely primary percutaneous coronary intervention PCI undertaken after enoxaparin and an oral loading dose of clopidogrel
The secondary objective of WEST is to compare clinical outcomes of patients receiving optimal pharmacologic therapy and a strategy of usual post-MI care Group A versus protocol-mandated early catheterisation and PCI Group B
The secondary objective of WEST is to compare clinical outcomes of patients receiving optimal pharmacologic therapy and a strategy of usual post-MI care Group A versus protocol-mandated early catheterisation and PCI Group B
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None