Ignite Creation Date:
2024-05-06 @ 1:28 AM
Last Modification Date:
2024-10-26 @ 11:04 AM
Study NCT ID:
NCT01819701
Status:
COMPLETED
Last Update Posted:
2014-03-13
First Post:
2013-03-15
Brief Title:
L-carnitine and Coenzyme Q10 in Relation to the Oxidative Stress Antioxidant Enzymes Activities Inflammation and the Risk of Coronary Artery Disease
Sponsor:
Taichung Veterans General Hospital
Organization:
Taichung Veterans General Hospital
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2014-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Cardiovascular disease CVD is the leading cause of Taiwan L-carnitine LC and coenzyme Q10 is recognized as lipid soluble antioxidants The purposes of this study are going to investigate the relation of LC and coenzyme Q10 with the markers of lipid peroxidation antioxidant enzymes activities and the inflammatory markers in coronary artery disease CAD patients The study is designed as a three-year study The first year is an observation study We will recruit CAD patients who are identified by cardiac catheterization as having at least 50 stenosis of one major coronary artery and age-gender matched healthy subjects The concentrations of LC coenzyme Q10 lipid peroxidation markers TBARS and ox-LDL antioxidant enzymes activities catalase glutathione peroxidase glutathione reductase and superoxide dismutase and inflammatory markers are going to analysis The second year is a single-blind single dose intervention study CAD subjects are recruit form the first year and randomly assigned to placebo coenzyme Q10-150 150 mgd coenzyme Q10-300 300 mgd LC-1000 1000 mgd or LC-2000 2000 mgd groups Intervention is going to administration for three months Fasting blood will be obtained in each month and determine the concentration of LC coenzyme Q10 lipid peroxidation markers antioxidant enzymes activities and inflammatory markers after intervention The third year is a single-blind multiple doses intervention study We are going to measure the CAD subjects from the second year intervention study After three months washout period the subjects are assigned to placebo coenzyme Q10-150 plus LC-1000 coenzyme Q10-150 plus LC-2000 coenzyme Q10-300 plus LC-1000 and coenzyme Q10-300 plus LC-2000 groups Intervention is going to administration for three months Fasting blood will be obtained in each month and determine the concentration of LC coenzyme Q10 lipid peroxidation markers antioxidant enzymes activities and inflammatory markers after intervention Hopefully the results of this study could provide information of LC and coenzyme Q10 supplementation for clinical dietitian in advising CAD patients
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None