Ignite Creation Date:
2024-05-06 @ 1:25 AM
Last Modification Date:
2024-10-26 @ 11:04 AM
Study NCT ID:
NCT01806025
Status:
COMPLETED
Last Update Posted:
2016-07-28
First Post:
2013-03-05
Brief Title:
Correlation Between Haptoglobin Phenotypes and Infectious and Other Complications in Cystic Fibrosis Patients
Sponsor:
Carmel Medical Center
Organization:
Carmel Medical Center
Study Overview
Official Title:
Correlation Between Haptoglobin Phenotypes and Infectious and Other Complications in Cystic Fibrosis Patients
Status:
COMPLETED
Status Verified Date:
2016-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
Hp-in-CF
Brief Summary:
Cystic Fibrosis is a genetic disease with variable severity and a predisposition for lung infection Usually severity is determined by the class of CF mutations but even among patients with the same severity of mutations there is a variation of the severity of CF
Haptoglobin has several types phenotypes one of them was found to be related to infectious complications
In this study the investigators aim to find a correlation between Haptoglobin phenotypes in patients with CF and frequency of infectious complications
To this end the investigators will collect serum from CF patients and determine their Haptoglobin protein phenotype The investigators will correlate Haptoglobin phenotype to retrospectively gathered data on infectious complications
Haptoglobin has several types phenotypes one of them was found to be related to infectious complications
In this study the investigators aim to find a correlation between Haptoglobin phenotypes in patients with CF and frequency of infectious complications
To this end the investigators will collect serum from CF patients and determine their Haptoglobin protein phenotype The investigators will correlate Haptoglobin phenotype to retrospectively gathered data on infectious complications
Detailed Description:
Cystic Fibrosis is a genetic disease with variable severity and a predisposition for lung infection The severity of the disease is determined by genetic factors type of mutation environmental factors exposure to bacteria and behavioral adherence with therapy Even among patients with the same severity of mutations there is a variation of the severity of CF
Haptoglobin is a protein responsible for collecting Iron from senescent Red Blood Cells There are two genes of Haptoglobin numbered 1 and 2 and combinations between the two genes create three forms of proteins 1-1 1-2 and 2-2 The 1-1 Phenotype was found to be associated with a predisposition to infection
In this study the investigators aim to find a correlation between Haptoglobin phenotypes in patients with CF and frequency of infectious complications
To this end the investigators will collect serum from CF patients and determine their Haptoglobin protein phenotype by gel- electrophoresis The investigators will correlate Haptoglobin phenotype to retrospectively gathered data on infectious complications
FEV1- Forced Expiratory Volume in 1 second
Haptoglobin is a protein responsible for collecting Iron from senescent Red Blood Cells There are two genes of Haptoglobin numbered 1 and 2 and combinations between the two genes create three forms of proteins 1-1 1-2 and 2-2 The 1-1 Phenotype was found to be associated with a predisposition to infection
In this study the investigators aim to find a correlation between Haptoglobin phenotypes in patients with CF and frequency of infectious complications
To this end the investigators will collect serum from CF patients and determine their Haptoglobin protein phenotype by gel- electrophoresis The investigators will correlate Haptoglobin phenotype to retrospectively gathered data on infectious complications
FEV1- Forced Expiratory Volume in 1 second
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None