Ignite Creation Date:
2024-05-05 @ 11:46 AM
Last Modification Date:
2024-10-26 @ 9:13 AM
Study NCT ID:
NCT00126087
Status:
TERMINATED
Last Update Posted:
2013-01-21
First Post:
2005-07-31
Brief Title:
Potentiation of Procedural Motor Learning in Health and Disease
Sponsor:
University Hospital Muenster
Organization:
University Hospital Muenster
Study Overview
Official Title:
Potentiation of Procedural Motor Learning by Pharmacological Neuromodulation and Transcranial Direct Current Stimulation in Health and Disease
Status:
TERMINATED
Status Verified Date:
2013-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
no further funding available for recruiting and testing participants
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The investigators plan to improve the learning of motor skills by pharmacological means dopamine and by noninvasive brain stimulation They will study both healthy subjects and chronic stroke patients In addition they want to study the mechanisms of enhanced learning on the molecular and the systems level
Detailed Description:
Adaptive behavior requires procedural motor learning ie the acquisition of motor skills Procedural learning is particularly critical in the rehabilitation of chronic motor deficits after stroke A potent modulator of motor function and learning is found in the endogenous dopaminergic system The investigators own work could demonstrate that formation of an elementary motor memory which constitutes the first step in acquiring more complex motor skills can be enhanced in both healthy subjects and chronic stroke patients by pre-medication with levodopa The aim of the present proposal is to
expand these exciting findings to procedural motor learning
explore the interaction with age brain lesions add-on interventions such as transcranial direct current stimulation tDCS and
illuminate the underlying mechanisms
The effect of levodopa - tDCS on procedural motor learning and cortical excitability will be studied in healthy volunteers and stroke patients Then the investigator plans to delineate the underlying mechanisms of this effect by exploring N-methyl-D-asparate NMDA receptor-dependency of levodopa-enhanced learning and changes in activation and connectivity using functional magnetic resonance imaging in the respective neural networks resulting from the interaction of learning and dopaminergic neuromodulation
expand these exciting findings to procedural motor learning
explore the interaction with age brain lesions add-on interventions such as transcranial direct current stimulation tDCS and
illuminate the underlying mechanisms
The effect of levodopa - tDCS on procedural motor learning and cortical excitability will be studied in healthy volunteers and stroke patients Then the investigator plans to delineate the underlying mechanisms of this effect by exploring N-methyl-D-asparate NMDA receptor-dependency of levodopa-enhanced learning and changes in activation and connectivity using functional magnetic resonance imaging in the respective neural networks resulting from the interaction of learning and dopaminergic neuromodulation
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None