Ignite Creation Date:
2024-05-05 @ 11:46 AM
Last Modification Date:
2024-10-26 @ 9:13 AM
Study NCT ID:
NCT00125853
Status:
COMPLETED
Last Update Posted:
2019-12-12
First Post:
2005-07-29
Brief Title:
The Effect of Nebivolol on Insulin Sensitivity
Sponsor:
Imperial College London
Organization:
Imperial College London
Study Overview
Official Title:
A Trial to Compare the Effects of Nebivolol Versus Atenolol on Various Cardiovascular Measurements Including Insulin Sensitivity
Status:
COMPLETED
Status Verified Date:
2019-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to conduct a randomised trial to compare the insulin sensitivity 24 hour blood pressure profile and tolerability of nebivolol plus a thiazide-like diuretic versus atenolol plus a thiazide-like diuretic
Detailed Description:
Retrospective studies of treated hypertensive cohorts have strongly implicated beta blocker therapy as increasing the risk of developing new-onset diabetes This has led to the latest British Hypertension Society guidelines advising caution when using beta blockers particularly in combination with thiazide-like diuretics However the National Institute of Clinical Excellence recommends beta-blocker thiazide combinations as the treatment of choice in patients who are not at increased risk of developing diabetes Nebivolol is a newer class of beta blocker Some studies in diabetic hypertensive patients have suggested that nebivolol does not impair insulin sensitivity The aim of this study is to compare the effect on insulin sensitivity of nebivolol versus atenolol both in combination with a thiazide-like diuretic in a group of non-diabetic hypertensive patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None