Ignite Creation Date:
2024-05-05 @ 11:46 AM
Last Modification Date:
2024-10-26 @ 9:13 AM
Study NCT ID:
NCT00127062
Status:
COMPLETED
Last Update Posted:
2019-11-05
First Post:
2005-08-04
Brief Title:
Health Effects of Diesel Exhaust in Asthmatic Patients A Real-world Study in a London Street
Sponsor:
Imperial College London
Organization:
Imperial College London
Study Overview
Official Title:
Health Effects of Diesel Exhaust in Asthmatic Patients A Real-world Study in a London Street
Status:
COMPLETED
Status Verified Date:
2019-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Acute exposure to diesel exhaust under normal city conditions leads to a worsening of symptoms of asthma with reduction in lung function in asthmatic nonsmoking adults dependent on the exposure dose and on the background severity of asthma
The worsening asthma is accompanied by increased oxidative stress and inflammation in the lungs
The worsening asthma is accompanied by increased oxidative stress and inflammation in the lungs
Detailed Description:
The investigators will recruit 60 nonsmoking asthmatics of mild and of moderate severity They will be exposed to Oxford St or to Hyde Park for 2 hours each at a walking pace Real time exposure to PM25 carbon monoxide and nitrogen dioxide will be made each time Health outcome measurements will be made before and after exposure to each street Statistical analyses will be made to examine the effect of diesel exposure on changes in health outcome measures
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None