Ignite Creation Date:
2024-05-05 @ 11:46 AM
Last Modification Date:
2024-10-26 @ 9:12 AM
Study NCT ID:
NCT00122759
Status:
UNKNOWN
Last Update Posted:
2007-07-23
First Post:
2005-07-19
Brief Title:
Ketamine Sedation in Mechanically Ventilated Patients
Sponsor:
Assistance Publique - Hôpitaux de Paris
Organization:
Assistance Publique - Hôpitaux de Paris
Study Overview
Official Title:
Prospective Study on the Cost-Effectiveness of Adding Ketamine to Midazolam-Sufentanil Sedation Regimen in Mechanically Ventilated Patients
Status:
UNKNOWN
Status Verified Date:
2007-07
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Adequate sedation is of paramount importance to avoid stress and pain in mechanically ventilated patients It is usually achieved by infusing sedatives benzodiazepine and analgesic opiate drugs
This combined sedation may not be sufficient in some instances
The aim of this study is to evaluate whether addition of a third substance ketamine allows the achievement of better sedation and avoids the use of neuromuscular blocking agents
This combined sedation may not be sufficient in some instances
The aim of this study is to evaluate whether addition of a third substance ketamine allows the achievement of better sedation and avoids the use of neuromuscular blocking agents
Detailed Description:
Mechanical ventilation is widely used in critically ill patients Sedation is used in most instances to alleviate symptoms of pain and distress It usually consists of an association of opiates and benzodiazepines
In some instances pain and agitation persist despite this combined sedation regimen In such cases the clinicians have the choice between increasing dosage of these 2 substances which may increase their adverse effects mainly hypotension andor adding a neuromuscular blocking agent which is not devoid of adverse effects mainly the onset of neuromyopathy of critical illness
This study will assess the safety efficacy and cost-effectiveness of adding ketamine a well known anesthetic agent to a combination of midazolam and sufentanil when this combination is not sufficient to reach acceptable sedation target
In some instances pain and agitation persist despite this combined sedation regimen In such cases the clinicians have the choice between increasing dosage of these 2 substances which may increase their adverse effects mainly hypotension andor adding a neuromuscular blocking agent which is not devoid of adverse effects mainly the onset of neuromyopathy of critical illness
This study will assess the safety efficacy and cost-effectiveness of adding ketamine a well known anesthetic agent to a combination of midazolam and sufentanil when this combination is not sufficient to reach acceptable sedation target
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None